Breast Cancer Research and Treatment

, Volume 114, Issue 2, pp 327–338

Association of genetic polymorphisms of ER-α and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women

Authors

  • Lina Zhang
    • Departments of Breast Oncology/SurgeryTianjin Medical University Cancer Institute and Hospital
    • Epidemiology and BiostatisticsTianjin Medical University Cancer Institute and Hospital
    • Departments of Breast Oncology/SurgeryTianjin Medical University Cancer Institute and Hospital
  • Biyun Qian
    • Epidemiology and BiostatisticsTianjin Medical University Cancer Institute and Hospital
  • Xishan Hao
    • Epidemiology and BiostatisticsTianjin Medical University Cancer Institute and Hospital
  • Wei Zhang
    • Departments of PathologyThe University of Texas M. D. Anderson Cancer Center
  • Qingyi Wei
    • EpidemiologyThe University of Texas M. D. Anderson Cancer Center
    • Epidemiology and BiostatisticsTianjin Medical University Cancer Institute and Hospital
Epidemiology

DOI: 10.1007/s10549-008-9998-0

Cite this article as:
Zhang, L., Gu, L., Qian, B. et al. Breast Cancer Res Treat (2009) 114: 327. doi:10.1007/s10549-008-9998-0

Abstract

Estrogen plays a role in breast cancer development, and genetic polymorphisms in estrogen receptor gene ER-α and genes regulating estrogen biosynthesis and metabolisms are associated with the risk of breast cancer in women in western countries. Therefore, we hypothesized that SNPs in ER-α and other estrogen-metabolizing genes contribute to breast cancer risk in Chinese women. In this study, we genotyped polymorphisms in the regulatory regions of ER-α (rs3798577) and other two estrogen-metabolizing enzyme genes CYP17 (rs743572) and CYP19 (rs10046) among 300 breast cancer cases and 390 controls in a Chinese population. Crude and adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression analyses to estimate breast cancer risk associated with these polymorphisms. We found that the T allele frequency of ER-α was significantly higher in cases (59.8%) than controls (54.5%) (= 0.047), but no significant difference was found in the genotype distribution. However, postmenopausal breast cancer risk was associated with the CYP17 TC genotype (aOR = 1.77, 95% CI = 1.11–2.83) compared with the TT genotype. The CYP19 variant TC + TT genotypes were associated with both overall cancer risk (TT + TC vs. TT aOR = 1.73, 95% CI = 1.13–2.65) and premenopausal cancer risk (TT + TC vs. TT aOR = 1.78, 95% CI = 1.03–3.09), particularly for ER +/PR + tumors. Furthermore, there were joint effects between CYP19 T and ER-α T varint genotypes (aOR = 1.67, 95% CI = 1.03–2.69 for CYP19 TC + TT vs. CC among ER-α T variant carriers) and between CYP19 T and CYP17 C variant genotypes (aOR = 1.77, 95% CI = 1.11–2.83 for CYP19 TC + TT vs. CC among CYP17 variant C carriers). This study provides evidence that polymorphisms CYP17 rs743572, CYP19 rs10046 and ER-α rs3798577 are associated with breast cancer risk among Chinese women.

Keywords

Case-control studyEstradiol-synthesizing enzymeSusceptible genotypeMolecular epidemiologyPolymorphism

Abbreviations

CYP17

The cytochrome P450c17α enzyme gene

CYP19

Aromatase gene

ER-α

Estrogen receptor α gene

CI

Confidence interval

OR

Odds ratio

SNP

Single nucleotide polymorphism

Copyright information

© Springer Science+Business Media, LLC. 2008