Breast Cancer Research and Treatment

, Volume 113, Issue 2, pp 383–391

Risk factors for arm lymphedema following breast cancer diagnosis in Black women and White women

  • Kathleen A. Meeske
  • Jane Sullivan-Halley
  • Ashley W. Smith
  • Anne McTiernan
  • Kathy B. Baumgartner
  • Linda C. Harlan
  • Leslie Bernstein
Epidemiology

DOI: 10.1007/s10549-008-9940-5

Cite this article as:
Meeske, K.A., Sullivan-Halley, J., Smith, A.W. et al. Breast Cancer Res Treat (2009) 113: 383. doi:10.1007/s10549-008-9940-5

Abstract

Purpose Lymphedema of the arm is a potential complication of breast cancer therapy. This study examines pre-disposing factors that may operate in conjunction with treatment-related factors in the development of arm lymphedema in a large cohort of White and Black breast cancer survivors. Methods 494 women (271 White and 223 Black) with in situ to Stage III-A primary breast cancer completed a baseline interview within 18 months of diagnosis. Information on lymphedema was collected during a follow-up interview, conducted on average 50 months after diagnosis. Self-reported data were used to classify women with or without lymphedema. Multivariable logistic regression models were developed to identify risk factors for arm lymphedema. Results Arm lymphedema was associated with younger age at diagnosis (odds ratio, OR per year of age = 0.96; 95% confidence interval, CI = 0.93–0.99), positive history of hypertension (OR = 2.31; 95% CI = 1.38–3.88), obesity (OR for body mass index, BMI≥30 = 2.48; 95% CI = 1.05–5.84) and having had surgery where 10 or more lymph nodes were excised (OR = 2.16; 95% CI = 1.12–4.17). While Black women had higher prevalence of arm lymphedema than White women (28% vs. 21%), race was not associated with lymphedema risk in models adjusted for multiple factors (adjusted OR = 1.01; 95% CI = 0.63–1.63). Conclusion Risk of arm lymphedema did not differ significantly for Black and White women. Risk factors identified in this study offer opportunities for interventions (weight loss, control of blood pressure, use of sentinel node biopsy where possible) for reducing incidence of lymphedema or controlling the symptoms associated with this condition.

Keywords

Breast cancer survivorsBlack breast cancer survivorsArm lymphedemaRisk factors for arm lymphedemaHypertensionBody mass indexRace

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Kathleen A. Meeske
    • 1
  • Jane Sullivan-Halley
    • 1
    • 2
  • Ashley W. Smith
    • 3
  • Anne McTiernan
    • 4
  • Kathy B. Baumgartner
    • 5
  • Linda C. Harlan
    • 3
  • Leslie Bernstein
    • 1
    • 2
  1. 1.Department of Preventive MedicineKeck School of Medicine of the University of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Cancer Etiology, Division of Population SciencesCity of Hope National Medical Center and Comprehensive Cancer CenterDuarteUSA
  3. 3.Applied Research Program, Division of Cancer Control and Population SciencesNational Cancer InstituteBethesdaUSA
  4. 4.Cancer Prevention Research ProgramFred Hutchinson Cancer Research CenterSeattleUSA
  5. 5.Department of Epidemiology & Population HealthUniversity of LouisvilleLouisvilleUSA