Breast Cancer Research and Treatment

, Volume 113, Issue 1, pp 181–187

Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive

Authors

  • Ben Van Calster
    • Multidisciplinary Breast CentreUZ Leuven
  • Isabelle Vanden Bempt
    • Multidisciplinary Breast CentreUZ Leuven
  • Maria Drijkoningen
    • Multidisciplinary Breast CentreUZ Leuven
  • Nathalie Pochet
    • Multidisciplinary Breast CentreUZ Leuven
  • Jiqiu Cheng
    • Multidisciplinary Breast CentreUZ Leuven
  • Sabine Van Huffel
    • Multidisciplinary Breast CentreUZ Leuven
  • Wouter Hendrickx
    • Multidisciplinary Breast CentreUZ Leuven
  • Julie Decock
    • Multidisciplinary Breast CentreUZ Leuven
  • Huei-Jean Huang
    • Multidisciplinary Breast CentreUZ Leuven
  • Karin Leunen
    • Multidisciplinary Breast CentreUZ Leuven
  • Frederic Amant
    • Multidisciplinary Breast CentreUZ Leuven
  • Patrick Berteloot
    • Multidisciplinary Breast CentreUZ Leuven
  • Robert Paridaens
    • Multidisciplinary Breast CentreUZ Leuven
  • Hans Wildiers
    • Multidisciplinary Breast CentreUZ Leuven
  • Erik Van Limbergen
    • Multidisciplinary Breast CentreUZ Leuven
  • Caroline Weltens
    • Multidisciplinary Breast CentreUZ Leuven
  • Dirk Timmerman
    • Multidisciplinary Breast CentreUZ Leuven
  • Toon Van Gorp
    • Multidisciplinary Breast CentreUZ Leuven
  • Ann Smeets
    • Multidisciplinary Breast CentreUZ Leuven
  • Walter Van den Bogaert
    • Multidisciplinary Breast CentreUZ Leuven
  • Ignace Vergote
    • Multidisciplinary Breast CentreUZ Leuven
  • Marie-Rose Christiaens
    • Multidisciplinary Breast CentreUZ Leuven
    • Multidisciplinary Breast CentreUZ Leuven
Epidemiology

DOI: 10.1007/s10549-008-9914-7

Cite this article as:
Van Calster, B., Vanden Bempt, I., Drijkoningen, M. et al. Breast Cancer Res Treat (2009) 113: 181. doi:10.1007/s10549-008-9914-7

Abstract

Aims To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status. Methods 2227 recently operated cases in one centre were retrieved from the Multidisciplinary Breast Centre database and stratified according to their combined immunohistochemical (IHC) expression of ER/PR/HER-2 status. An equivocal HER-2 status was further analysed by Fluorescence in situ Hybridisation (FISH). The following 6 groups were considered: ERPRHER-2 (NNN; triple negative), ERPRHER-2+ (NNP), ER+PRHER-2 (PNN), ER+PRHER-2+ (PNP), ER+PR+HER-2(PPN), ER+PR+HER-2+ (PPP; triple positive). For ALN, the following variables were tested in uni- and multivariate models: age at diagnosis (years), tumour size (mm), tumour grade, ER, PR, HER-2 and the combined steroid receptor and HER-2 status. Likelihood ratio χ2-tests were used for univariate analysis and logistic regression for multivariate analysis. Results Triple positive tumours had a higher likelihood of being ALN positive than others (56.2% versus 35.7%; P < 0.0001). Univariate logistic regression also withheld age, size, grade and HER-2 as predictors of ALN involvement. Final multivariate logistic regression revealed age, size, grade and PPP versus non-PPP to be independent predictors of ALN involvement; the odds ratio (OR) and 95% CI for PPP versus non-PPP tumours was 2.169 (1.490–3.156). Conclusion Our data provide insight into the natural history of triple positive breast carcinomas. Such tumours are more likely ALN positive than those with another steroid receptor and HER-2 status. How these findings correlate with breast cancer prognosis remains to be investigated.

Keywords

HER-2Steroid receptorsLymph nodeBreast cancer

Copyright information

© Springer Science+Business Media, LLC. 2008