Breast Cancer Research and Treatment

, Volume 117, Issue 2, pp 381–389

Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS)

  • Tsogzolmaa Dorjgochoo
  • Yu-Tang Gao
  • Wong-Ho Chow
  • Xiao-Ou Shu
  • Honglan Li
  • Gong Yang
  • Qiuyin Cai
  • Nathaniel Rothman
  • Hui Cai
  • Adrian A. Franke
  • Wei Zheng
  • Qi Dai
Epidemiology

DOI: 10.1007/s10549-008-0270-4

Cite this article as:
Dorjgochoo, T., Gao, YT., Chow, WH. et al. Breast Cancer Res Treat (2009) 117: 381. doi:10.1007/s10549-008-0270-4

Abstract

Evidence from some previous studies suggests that lipophilic antioxidants, particularly carotenoids, may reduce the risk of breast cancer. We prospectively investigated the associations of plasma levels of tocopherols, retinol, carotenoids with the risk of developing breast cancer among Chinese women. We conducted a study of 365 incident breast cancer cases and 726 individually matched controls nested within a large cohort study of women aged 40–70 years at baseline. We observed no associations between breast cancer risk and any of the tocopherols, retinol, and most carotenoids. However, high levels of plasma lycopene other than trans, 5- and 7-cis or trans α-cryptoxanthin were inversely associated with the risk of developing breast cancer. Our results do not support an overall protective effect of lipophilic antioxidants on breast cancer risk. The few inverse associations observed for subtype of carotenoids may need to be confirmed in future studies.

Keywords

Lipophilic antioxidants Breast cancer Plasma 

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Tsogzolmaa Dorjgochoo
    • 1
  • Yu-Tang Gao
    • 3
  • Wong-Ho Chow
    • 2
  • Xiao-Ou Shu
    • 1
  • Honglan Li
    • 3
  • Gong Yang
    • 1
  • Qiuyin Cai
    • 1
  • Nathaniel Rothman
    • 2
  • Hui Cai
    • 1
  • Adrian A. Franke
    • 4
  • Wei Zheng
    • 1
  • Qi Dai
    • 1
    • 5
  1. 1.Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer CenterVanderbilt University School of MedicineNashvilleUSA
  2. 2.Department of Health and Human Services, Division of Cancer Epidemiology and GeneticsNational Cancer Institute, NIHBethesdaUSA
  3. 3.Department of EpidemiologyShanghai Cancer InstituteShanghaiChina
  4. 4.Cancer Research Center of HawaiiUniversity of HawaiiHonoluluUSA
  5. 5.Vanderbilt Epidemiology CenterInstitute for Medicine and Public HealthNashvilleUSA

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