Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users

  • Sharon J. Wayne
  • Marian L. Neuhouser
  • Carol Koprowski
  • Cornelia M. Ulrich
  • Charles Wiggins
  • Frank Gilliland
  • Kathy B. Baumgartner
  • Richard N. Baumgartner
  • Anne McTiernan
  • Leslie Bernstein
  • Rachel Ballard-Barbash
Epidemiology

DOI: 10.1007/s10549-008-0224-x

Cite this article as:
Wayne, S.J., Neuhouser, M.L., Koprowski, C. et al. Breast Cancer Res Treat (2009) 117: 111. doi:10.1007/s10549-008-0224-x

Abstract

To measure the association between use of estrogenic botanical supplements and serum sex hormones in postmenopausal breast cancer survivors, a total 502 postmenopausal women were queried 2–3 years after breast cancer diagnosis about their use of botanical supplements, and supplements were categorized according to their estrogenic properties. Concurrently, a fasting blood sample was obtained for assay of estrone, estradiol, free estradiol, testosterone, free testosterone, dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin. Adjusted means of the serum hormones were calculated by use of estrogenic supplements. Women reporting use of any estrogenic botanical supplement had significantly lower levels of estrone (20.8 vs. 23.6 pg/ml), estradiol (12.8 vs. 14.7 pg/ml), free estradiol (0.29 vs. 0.35 pg/ml), and DHEAS (47.7 vs. 56.2 µg/dl) compared to women reporting no use. Data from this cross-sectional study suggest the use of estrogenic botanical supplements may be associated with sex hormone concentrations in breast cancer survivors. Considering the high use of these supplements among breast cancer patients, further research is needed to clarify the relative estrogenicity/antiestrogenicity of these compounds and their relation with prognosis.

Keywords

Breast cancer Estrogenic botanical supplements Serum sex hormones 

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Sharon J. Wayne
    • 1
  • Marian L. Neuhouser
    • 2
  • Carol Koprowski
    • 3
  • Cornelia M. Ulrich
    • 2
  • Charles Wiggins
    • 1
  • Frank Gilliland
    • 3
  • Kathy B. Baumgartner
    • 4
  • Richard N. Baumgartner
    • 4
  • Anne McTiernan
    • 2
  • Leslie Bernstein
    • 5
  • Rachel Ballard-Barbash
    • 6
  1. 1.New Mexico Tumor Registry, MSC 11 620, 1University of New MexicoAlbuquerqueUSA
  2. 2.Fred Hutchinson Cancer Research CenterSeattleUSA
  3. 3.Department of Preventive MedicineUniversity of Southern CaliforniaLos AngelesUSA
  4. 4.Department of Epidemiology and Population HealthUniversity of LouisvilleLouisvilleUSA
  5. 5.City of Hope National Medical CenterDuarteUSA
  6. 6.Applied Research ProgramNational Cancer InstituteBethesdaUSA

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