Breast Cancer Research and Treatment

, 115:365

Psychological impact of recall in high-risk breast MRI screening

Authors

  • Suzanne M. O’Neill
    • Department of MedicineNorthwestern University Feinberg School of Medicine
    • Center for Medical GeneticsEvanston Northwestern Healthcare
    • Department of MedicineNorthwestern University Feinberg School of Medicine
    • Center for Medical GeneticsEvanston Northwestern Healthcare
  • Stephen F. Sener
    • Department of SurgeryNorthwestern University Feinberg School of Medicine
  • Scott M. Weissman
    • Department of MedicineNorthwestern University Feinberg School of Medicine
    • Center for Medical GeneticsEvanston Northwestern Healthcare
  • Anna C. Newlin
    • Department of MedicineNorthwestern University Feinberg School of Medicine
    • Center for Medical GeneticsEvanston Northwestern Healthcare
  • Daniel K. West
    • Department of RadiologyNorthwestern University Feinberg School of Medicine
  • David B. Ecanow
    • Department of RadiologyNorthwestern University Feinberg School of Medicine
  • Alfred W. Rademaker
    • Department of Preventive MedicineNorthwestern University Feinberg School of Medicine
  • Robert R. Edelman
    • Department of RadiologyNorthwestern University Feinberg School of Medicine
Clinical Trial

DOI: 10.1007/s10549-008-0140-0

Cite this article as:
O’Neill, S.M., Rubinstein, W.S., Sener, S.F. et al. Breast Cancer Res Treat (2009) 115: 365. doi:10.1007/s10549-008-0140-0

Abstract

Purpose To address the widespread concern that false-positive results during breast MRI screening may have adverse psychological effects. Methods Impact of Event Scale measurements in 103 high-risk women enrolled in a longitudinal MRI screening study and comparison of subjects with normal results vs. those with prior recall events. Results Of 189 MRI scans performed, 64 (34%) prompted further evaluation. Subjects with previously abnormal results had significantly higher Avoidance scores at the time of their second MRI. Multivariate analysis showed this was driven by the greater number of BRCA1/2 carriers in that group but was not related to screening recall. Conclusions Practitioners’ concerns about the high false positive rate of breast MRI may not be matched by actual psychological effects in most high-risk women.

Keywords

Psychological stressBreast neoplasms/geneticsMagnetic resonance imaging/adverse effectsSensitivity and specificityBRCA1 genesBRCA2 genes

Copyright information

© Springer Science+Business Media, LLC. 2008