Breast Cancer Research and Treatment

, Volume 112, Issue 1, pp 149–158

Dietary fiber is associated with serum sex hormones and insulin-related peptides in postmenopausal breast cancer survivors

  • Sharon J. Wayne
  • Marian L. Neuhouser
  • Cornelia M. Ulrich
  • Carol Koprowski
  • Kathy B. Baumgartner
  • Richard N. Baumgartner
  • Anne McTiernan
  • Leslie Bernstein
  • Rachel Ballard-Barbash
Epidemiology

DOI: 10.1007/s10549-007-9834-y

Cite this article as:
Wayne, S.J., Neuhouser, M.L., Ulrich, C.M. et al. Breast Cancer Res Treat (2008) 112: 149. doi:10.1007/s10549-007-9834-y

Abstract

Objective To measure the association between dietary fiber intake and eleven hormones and peptides in postmenopausal breast cancer survivors. Methods Intake of fiber from food and supplements was measured two to three years after breast cancer diagnosis in 493 postmenopausal women from three western states. Concurrently, a fasting blood sample was obtained for assay of estrone, estradiol, free estradiol, testosterone, free testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG), leptin, C-peptide, insulin-like growth factor-1 (IGF1), and IGF-binding protein-3. Adjusted means of these hormones and peptides were calculated for categories of fiber intake. Results High intake of dietary fiber was significantly (≤ 0.05) associated with low serum levels of estradiol and free estradiol and with high serum levels of IGF1. The combination of high dietary fiber intake and use of fiber supplements was additionally associated with low serum levels of C-peptide. The magnitude of the difference in hormone/peptide values, comparing high fiber intake to low fiber intake, varied from 16 to 28%, and the associations were independent of multiple confounding variables. Conclusion High fiber diets may be beneficial to postmenopausal breast cancer survivors due to fiber’s favorable influence on sex hormones and peptides known to affect breast cancer prognosis.

Keywords

Breast cancer outcomes Dietary fiber Serum hormones Serum peptides 

Copyright information

© Springer Science+Business Media, LLC. 2007

Authors and Affiliations

  • Sharon J. Wayne
    • 1
  • Marian L. Neuhouser
    • 2
  • Cornelia M. Ulrich
    • 2
  • Carol Koprowski
    • 3
  • Kathy B. Baumgartner
    • 4
  • Richard N. Baumgartner
    • 4
  • Anne McTiernan
    • 2
  • Leslie Bernstein
    • 5
  • Rachel Ballard-Barbash
    • 6
  1. 1.New Mexico Tumor Registry, MSC 11 6201 University of New MexicoAlbuquerqueUSA
  2. 2.Fred Hutchinson Cancer Research CenterSeattleUSA
  3. 3.Institute for Health Promotion and Disease PreventionUniversity of Southern CaliforniaAlhambraUSA
  4. 4.Department of Epidemiology and Population HealthUniversity of LouisvilleLouisvilleUSA
  5. 5.City of Hope National Medical CenterDuarteUSA
  6. 6.Applied Research ProgramNational Cancer InstituteBethesdaUSA