Breast Cancer Research and Treatment

, Volume 111, Issue 3, pp 405–410

Mammographic features of triple receptor-negative primary breast cancers in young premenopausal women

  • Wei-Tse Yang
  • Mark Dryden
  • Kristine Broglio
  • Michael Gilcrease
  • Shaheenah Dawood
  • Peter J. Dempsey
  • Vicente Valero
  • Gabriel Hortobagyi
  • Deann Atchley
  • Banu Arun
Review

DOI: 10.1007/s10549-007-9810-6

Cite this article as:
Yang, W., Dryden, M., Broglio, K. et al. Breast Cancer Res Treat (2008) 111: 405. doi:10.1007/s10549-007-9810-6

Abstract

Background The mammographic features of triple receptor-negative [TRN] breast cancers, a distinct cancer subtype with a poor prognosis have not been reported to our knowledge. The aim of this study was to compare the mammographic breast density, visibility, and tumor features of different breast cancer immunophenotypes. Patients and methods We identified all premenopausal women aged 45 years or less who had been diagnosed with primary breast cancer between January 1999 and November 2005 at a single institution and who had undergone mammography at initial diagnosis. Patient characteristics including clinical, histologic, and mammographic features of breast cancers were tabulated by immunophenotype and compared with the chi-square test or the Kruskal–Wallis test. The P values less than 0.05 were considered statistically significant. Results We identified 198 premenopausal women who had been diagnosed with breast cancer. Thirty-eight (19%) women had TRN cancer, 67 (34%) had HER2+ cancer, and 93 (47%) had ER+ cancer. Mammographic density and cancer visibility were similar between all immunophenotypes of cancers. TRN cancers were more frequently associated with a mass (33/33 [100%]) than were HER2+ (35/64 [55%]) and ER+ cancers (42/87 [48%]) (P < 0.0001), and were less frequently associated with calcifications (5/33 [15%]) than were HER2+ (43/64 [67%]) and ER+ (53/87 [61%]) cancers (P < 0.0001). Associated ductal carcinoma in situ was reported in 18% (7/38), 57% (38/67), and 48% (52/93) of TRN, HER2+, and ER+ patients, respectively (P = 0.0003). Conclusion The mammographic features of TRN breast cancer suggest more rapid carcinogenesis leading directly to invasive cancer, that may require adjunct imaging tools for early diagnosis.

Keywords

MammographyTriple receptor-negativeBreast cancerBreast densityMicrocalcifications

Copyright information

© Springer Science+Business Media, LLC. 2007

Authors and Affiliations

  • Wei-Tse Yang
    • 1
  • Mark Dryden
    • 1
  • Kristine Broglio
    • 2
  • Michael Gilcrease
    • 3
  • Shaheenah Dawood
    • 4
  • Peter J. Dempsey
    • 1
  • Vicente Valero
    • 4
  • Gabriel Hortobagyi
    • 4
  • Deann Atchley
    • 4
  • Banu Arun
    • 4
  1. 1.Department of Diagnostic RadiologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of BiostatisticsThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  3. 3.Department of PathologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  4. 4.Department of Breast Medical OncologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA