Breast Cancer Research and Treatment

, Volume 109, Issue 1, pp 9–26

Progressive resistance training in breast cancer: a systematic review of clinical trials

  • Bobby Cheema
  • Catherine A. Gaul
  • Kirstin Lane
  • Maria A. Fiatarone Singh
Review

DOI: 10.1007/s10549-007-9638-0

Cite this article as:
Cheema, B., Gaul, C.A., Lane, K. et al. Breast Cancer Res Treat (2008) 109: 9. doi:10.1007/s10549-007-9638-0

Abstract

Background

Progressive resistance training (PRT) may be effective for targeting the sequelae of breast cancer and its treatment given the unique anabolic nature of this exercise modality. Therefore, our objectives were: (1) to systematically review studies that have prescribed PRT after breast cancer surgery, (2) to summarize the efficacy of PRT in this cohort, and (3) to delineate areas for future investigations.

Method

A systematic review using computerized databases was performed.

Results

The systematic review located 10 trials: Four uncontrolled trials, one controlled trial and five randomized controlled trials (RCTs). PRT was prescribed with aerobic training in 8/10 trials reviewed, and in isolation in 2/10 trials reviewed. Upper body PRT was prescribed in 7/10 trials, including 4/5 RCTs. No exacerbation of objectively measured or subjectively reported lymphedema symptoms was reported in any of these trials. Adverse events were rare, generally musculoskeletal in nature, and were managed effectively by conservative means. Overall, the studies we reviewed suggest that women surgically treated for breast cancer can derive health-related and clinical benefits by performing PRT after breast cancer surgery. Further research may be required to stimulate greater advocacy for PRT among oncologists, and in community care settings.

Conclusions

Robustly designed RCTs prescribing targeted PRT regimens throughout various phases of breast cancer treatment are warranted. RCTs with thorough, standardized reporting of interventions and adverse events are required to establish the efficacy of this intervention for the post-treatment management of breast cancer patients and survivors as a means to improve health status and quality of life.

Keywords

WomenUpper BodyExerciseQuality of LifeLymphedema

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Bobby Cheema
    • 1
  • Catherine A. Gaul
    • 2
  • Kirstin Lane
    • 3
  • Maria A. Fiatarone Singh
    • 4
    • 5
    • 6
  1. 1.Institute of Food, Nutrition and Human Health, Te Kura Hangarua o Kai-oranga-a-tangataMassey UniversityWellingtonNew Zealand
  2. 2.School of Physical EducationUniversity of VictoriaVictoriaCanada
  3. 3.Department of MedicineUniversity of British ColumbiaVancouverCanada
  4. 4.School of Exercise and Sport Science and Faculty of MedicineUniversity of SydneySydneyAustralia
  5. 5.Hebrew SeniorLifeBostonUSA
  6. 6.Jean Mayer USDA Human Nutrition Center on Aging at Tufts UniversityBostonUSA