Breast Cancer Research and Treatment

, Volume 109, Issue 1, pp 143–155

Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women

Authors

  • Lori C. Sakoda
    • Program in Epidemiology, Division of Public Health SciencesFred Hutchinson Cancer Research Center
    • Department of EpidemiologyUniversity of Washington
  • Christie R. Blackston
    • Program in Epidemiology, Division of Public Health SciencesFred Hutchinson Cancer Research Center
  • Kan Xue
    • Zhongshan HospitalFudan University
  • Jennifer A. Doherty
    • Program in Epidemiology, Division of Public Health SciencesFred Hutchinson Cancer Research Center
  • Roberta M. Ray
    • Program in Epidemiology, Division of Public Health SciencesFred Hutchinson Cancer Research Center
  • Ming Gang Lin
    • Program in Cancer Biology, Division of Public Health SciencesFred Hutchinson Cancer Research Center
    • Division of Human BiologyFred Hutchinson Cancer Research Center
  • Helge Stalsberg
    • Institute of Medical BiologyUniversity of Tromsø
  • Dao Li Gao
    • Department of Epidemiology, Zhongshan Hospital Cancer CenterFudan University
  • Ziding Feng
    • Program in Biostatistics and Bioinformatics, Division of Public Health SciencesFred Hutchinson Cancer Research Center
  • David B. Thomas
    • Department of EpidemiologyUniversity of Washington
    • Program in Epidemiology, Division of Public Health SciencesFred Hutchinson Cancer Research Center
    • Department of EpidemiologyUniversity of Washington
    • Program in Epidemiology, Division of Public Health SciencesFred Hutchinson Cancer Research Center
Epidemiology

DOI: 10.1007/s10549-007-9633-5

Cite this article as:
Sakoda, L.C., Blackston, C.R., Xue, K. et al. Breast Cancer Res Treat (2008) 109: 143. doi:10.1007/s10549-007-9633-5

Abstract

Enzymes encoded by the glutathione S-tranferase mu 1 (GSTM1) and pi 1 (GSTP1) genes, which are expressed in breast tissue, catalyze the detoxification of endogenous and exogenous electrophiles. Reduced enzyme activity, due to carriage of the GSTM1 deletion or the GSTP1 Ile105Val Val allele, may therefore affect susceptibility to breast cancer and related conditions. In a case-control study of Chinese women, we examined whether these polymorphisms were associated with risk of breast cancer and fibrocystic breast conditions. Women diagnosed with breast cancer (n = 615) or fibrocystic breast conditions (n = 467) were compared to women without clinical breast disease (n = 878). We also examined whether these associations differed by menopausal status or by presence of proliferation in the extra-tumoral epithelium among women with breast cancer and in lesions among women with fibrocystic conditions. No overall association of either GST polymorphism with risk of breast cancer or fibrocystic breast conditions was observed. There was some evidence of slightly elevated cancer risk associated with carriage of the GSTM1 null genotype and at least one GSTP1 105–Val allele (OR = 1.33, 95% CI, 0.99–1.80), compared to carriage of the GSTM1 non-null and GSTP1 Ile/Ile genotypes. This relationship was stronger in women who had breast cancer with extra-tumoral tissue proliferation (OR = 1.77, 95% CI, 1.03–3.04). Our results suggest that GSTM1 and GSTP1 genotypes do not individually influence susceptibility to breast cancer or fibrocystic breast conditions. The observed increased risk of breast cancer associated with joint carriage of the GSTM1 null genotype and GSTP1 105–Val allele needs confirmation in other studies.

Keywords

Breast cancerChineseFibrocystic breast conditionsGlutathione S-transferasePolymorphism

Abbreviations

GST

Glutathione S-transferase

BSE

Breast self examination

PCR

Polymerase chain reaction

OR

Odds ratio

CI

Confidence interval

ITC

Isothiocynates

Copyright information

© Springer Science+Business Media, LLC 2007