Breast Cancer Research and Treatment

, Volume 106, Issue 2, pp 281–288

Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry

  • Mary Beth Terry
  • Julia A. Knight
  • Lydia Zablotska
  • Qiao Wang
  • Esther M. John
  • Irene L. Andrulis
  • Ruby T. Senie
  • Mary Daly
  • Hilmi Ozcelik
  • Laurent Briollais
  • Regina M. Santella
Epidemiology

DOI: 10.1007/s10549-007-9498-7

Cite this article as:
Terry, M.B., Knight, J.A., Zablotska, L. et al. Breast Cancer Res Treat (2007) 106: 281. doi:10.1007/s10549-007-9498-7

Abstract

Moderate alcohol intake has been consistently associated with a modest (30–50%) increase in breast cancer risk, but it remains unclear if certain individuals have higher susceptibility to the harmful effects of alcohol intake. Individuals differ in their ability to metabolize alcohol through genetic differences in alcohol dehydrogenase (ADH), the enzyme that catalyzes the oxidation of approximately 80% of ethanol to acetaldehyde, a known carcinogen. Using data from the Breast Cancer Family Registry (n = 811 sister sets), we examined whether sisters with breast cancer differ with respect to alcohol consumption and alcohol metabolism (measured by polymorphisms in ADH1B and ADH1C) compared to their sisters without breast cancer. Neither alcohol drinking nor alcohol metabolizing ADH1B and ADH1C genotypes were associated with breast cancer risk. However, only 19% and 42% of sisters were discordant by ADH1B and ADH1C, respectively, and even fewer were discordant by both genotype and alcohol intake, making it difficult to detect differences if they existed.

Keywords

Breast cancer Alcohol Alcohol dehydrogenase 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Mary Beth Terry
    • 1
    • 2
  • Julia A. Knight
    • 3
  • Lydia Zablotska
    • 1
  • Qiao Wang
    • 4
  • Esther M. John
    • 5
  • Irene L. Andrulis
    • 6
    • 7
  • Ruby T. Senie
    • 1
    • 2
  • Mary Daly
    • 8
  • Hilmi Ozcelik
    • 7
  • Laurent Briollais
    • 3
  • Regina M. Santella
    • 2
    • 4
  1. 1.Department of Epidemiology, Mailman School of Public HealthColumbia UniversityNew YorkUSA
  2. 2.Herbert Irving Comprehensive Cancer Center, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Prosserman Centre for Health Research, Samuel Lunenfeld Research InstituteMount Sinai HospitalTorontoCanada
  4. 4.Department of Environmental Health Sciences, Mailman School of Public HealthColumbia University New YorkUSA
  5. 5.Northern California Cancer CenterFremontUSA
  6. 6.Ontario Cancer Genetics NetworkCancer Care OntarioTorontoCanada
  7. 7.Fred Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research InstituteMount Sinai HospitalTorontoCanada
  8. 8.Fox Chase Cancer CenterPhiladelphiaUSA

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