Breast Cancer Research and Treatment

, Volume 99, Issue 1, pp 47–57

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

  • Bette J. Caan
  • Jennifer A. Emond
  • Loki Natarajan
  • Adrienne Castillo
  • Erica P. Gunderson
  • Laurel Habel
  • Lovell Jones
  • Vicky A. Newman
  • Cheryl L. Rock
  • Martha L. Slattery
  • Marcia L. Stefanick
  • Barbara Sternfeld
  • Cynthia A. Thomson
  • John P. Pierce
Epidemiology

DOI: 10.1007/s10549-006-9179-y

Cite this article as:
Caan, B.J., Emond, J.A., Natarajan, L. et al. Breast Cancer Res Treat (2006) 99: 47. doi:10.1007/s10549-006-9179-y

Summary

Purpose

To examine whether weight gain after diagnosis of breast cancer affects the risk of breast cancer recurrence.

Patient and methods

Patients included 3215 women diagnosed with early stage breast cancer (Stage I >1 cm., II, and IIIA) who were enrolled either in an observational cohort of breast cancer survivors or were part of the comparison group of a dietary intervention trial to prevent breast cancer recurrence. We computed weight change from 1 year prior to diagnosis to study enrollment. Delayed entry Cox proportional hazards models were used to evaluate associations of categories of weight change with time to recurrence, controlling for known prognostic factors.

Results

Neither moderate (5–10%) nor large (> 10%) weight gain (HR 0.8, 95% CI, 0.6–1.1; HR 0.9, 95% CI, 0.7–1.2, respectively) after breast cancer diagnosis was associated with an increased risk of breast cancer recurrence in the early years post-diagnosis (median time of 73.7 months from diagnosis).

Conclusion

Our research provides evidence that weight gain commonly seen in the first several years following a breast cancer diagnosis does not increase a woman’s risk for breast cancer recurrence in the first 5–7 years post-diagnosis. However, this research does not address the effects of weight gain on overall survival or on the risk of other new cancers, other prognostic outcomes of concern to the breast cancer survivor.

Keywords

BMIbreast cancerprognosisrecurrenceweight gain

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Bette J. Caan
    • 1
  • Jennifer A. Emond
    • 2
  • Loki Natarajan
    • 1
  • Adrienne Castillo
    • 1
  • Erica P. Gunderson
    • 1
  • Laurel Habel
    • 1
  • Lovell Jones
    • 3
  • Vicky A. Newman
    • 2
  • Cheryl L. Rock
    • 2
  • Martha L. Slattery
    • 4
  • Marcia L. Stefanick
    • 5
  • Barbara Sternfeld
    • 1
  • Cynthia A. Thomson
    • 6
  • John P. Pierce
    • 2
  1. 1.Division of ResearchKaiser Permanente Medical GroupOaklandUSA
  2. 2.Division of Biostatistics, Departments of Family and Preventive Medicine, and Cancer Prevention and Control ProgramUniversity of CaliforniaSan DiegoUSA
  3. 3.MD Anderson Cancer CenterUniversity of TexasHoustonUSA
  4. 4.Health Research CenterUniversity of UtahSalt Lake CityUSA
  5. 5.Department of Medicine, Stanford Prevention Research CenterStanford UniversityStanfordUSA
  6. 6.Arizona Cancer CenterUniversity of ArizonaArizonaUSA
  7. 7.Division of ResearchKaiser Permanente Medical GroupOaklandUSA