Breast Cancer Research and Treatment

, Volume 99, Issue 1, pp 19–21

Prediction of breast cancer using volatile biomarkers in the breath

  • Michael Phillips
  • Renee N. Cataneo
  • Beth Ann Ditkoff
  • Peter Fisher
  • Joel Greenberg
  • Ratnasiri Gunawardena
  • C. Stephan Kwon
  • Olaf Tietje
  • Cynthia Wong
Article

DOI: 10.1007/s10549-006-9176-1

Cite this article as:
Phillips, M., Cataneo, R.N., Ditkoff, B.A. et al. Breast Cancer Res Treat (2006) 99: 19. doi:10.1007/s10549-006-9176-1

Summary

We evaluated a breath test for volatile organic compounds (VOCs) as a predictor of breast cancer. Breath VOCs were assayed in 51 asymptomatic women with abnormal mammograms and biopsy-proven breast cancer, and 42 age-matched healthy women. A fuzzy logic model predicted breast cancer with accuracy superior to previously reported findings. Following random assignment to a training set (64) or a prediction set (29), a model was constructed in the training set employing five breath VOCs that predicted breast cancer in the prediction set with 93.8% sensitivity and 84.6% specificity. The same model predicted no breast cancer in 16/50 (32.0%) women with abnormal mammograms and no cancer on biopsy. A two-minute breath test could potentially provide a safe, accurate and painless screening test for breast cancer, but prospective validation studies are required.

Keywords

breast cancer breath prediction volatile organic compounds 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Michael Phillips
    • 1
    • 2
    • 8
  • Renee N. Cataneo
    • 1
  • Beth Ann Ditkoff
    • 3
  • Peter Fisher
    • 4
  • Joel Greenberg
    • 1
  • Ratnasiri Gunawardena
    • 5
  • C. Stephan Kwon
    • 6
  • Olaf Tietje
    • 7
  • Cynthia Wong
    • 2
    • 5
  1. 1.Menssana Research Inc.Fort LeeUSA
  2. 2.Department of MedicineNew York Medical CollegeValhallaUSA
  3. 3.Department of SurgeryColumbia University Medical CenterNew YorkUSA
  4. 4.Department of PathologyColumbia University Medical CenterNew YorkUSA
  5. 5.Department of MedicineSaint Vincents Catholic Medical Centers of New YorkStaten Island RegionUSA
  6. 6.Department of Laboratory MedicineSaint Vincents Catholic Medical Centers of New YorkStaten Island RegionUSA
  7. 7.SystAim GmbHZürichSwitzerland
  8. 8.Menssana Research Inc.Fort LeeUSA