Breast Cancer Research and Treatment

, 97:179

Prospective study of electrical impedance scanning for identifying young women at risk for breast cancer

Authors

    • Walter Reed Army Medical Center
    • Walter Reed Army Medical Center
  • Orah Moskovitz
    • Machon Or, Bnei Zion Hospital
  • Zahava Gallimidi
    • Rambam Hospital
  • Scott Fields
    • Hadassah University Hospital
  • Ari D. Brooks
    • Drexel University College of Medicine
  • Rachel Brem
    • George Washington University
  • Robert N. Mucciola
    • East Hills Ob/Gyn Clinic
  • Mukul Singh
    • Cornell Medical Center
  • Mary Maniscalco-Theberge
    • Walter Reed Army Medical Center
  • Howard E. Rockette
    • University of Pittsburgh and Magee-Women’s Hospital
  • David Gur
    • University of Pittsburgh and Magee-Women’s Hospital
  • Craig D. Shriver
    • Walter Reed Army Medical Center
Clinical trial

DOI: 10.1007/s10549-005-9109-4

Cite this article as:
Stojadinovic, A., Moskovitz, O., Gallimidi, Z. et al. Breast Cancer Res Treat (2006) 97: 179. doi:10.1007/s10549-005-9109-4

Summary

Background

One way to improve the cost-benefit ratio for breast cancer screening in younger women is to identify those at high-risk of breast cancer and manage them in an optimal manner. The purpose of this study is to evaluate the sensitivity and specificity of Electrical Impedance Scanning (EIS) for identifying young women who are at risk for having breast cancer and should be followed with directed imaging technologies.

Methods

A prospective, observational, two-arm, multi-site clinical trial was performed on women aged 30–45 years. The ‘Sensitivity Arm’ included Clinical Breast Examinations (CBE) and EIS (T-Scan™ 2000ED) on 189 women prior to scheduled breast biopsy. The ‘Specificity Arm’ included 1361 asymptomatic women visiting clinics for routine annual well-woman examination. Sensitivity and specificity were determined. Relative probability for a woman with a positive EIS examination was computed and compared with other approaches commonly used to define ‘high-risk’ in this population.

Results

Fifty of 189 women in the Sensitivity arm had verified cancers, 19 of whom had positive EIS examination resulting in sensitivity of 38% (19/50). Of the 1361 women in the Specificity arm, 67 had positive EIS examination resulting in a specificity of 95% (1294/1361). The relative probability of a woman with a positive EIS examination was 7.68, which compares favorably with other established risk identifiers (e.g. two first-degree relatives with breast cancer or atypical ductal hyperplasia).

Conclusion

EIS may have an important role as a screening tool for identifying young women that should be followed more closely with advanced imaging technologies for early detection of breast cancer.

Keywords

electrical impedancescreening breast cancer

Copyright information

© Springer 2005