Breast Cancer Research and Treatment

, Volume 96, Issue 1, pp 91–95

PIK3CA mutations in breast cancer are associated with poor outcome

  • Shao Ying Li
  • Minna Rong
  • Fabienne Grieu
  • Barry Iacopetta
Original Report

DOI: 10.1007/s10549-005-9048-0

Cite this article as:
Li, S.Y., Rong, M., Grieu, F. et al. Breast Cancer Res Treat (2006) 96: 91. doi:10.1007/s10549-005-9048-0

Summary

The phosphatidylinositol-3-kinase (PI3K)–AKT signaling pathway is considered to play an important role in tumorigenesis. Frequent somatic mutations in the PI3K subunit p110α (PIK3CA) occur in a variety of cancer types. We screened 250 primary human breast tumors for mutations in PIK3CA in order to determine associations with pathological features and with patient outcome. The frequency of PIK3CA mutations in the C2, helical and kinase domains was 35% (88/250). Mutations were associated with larger tumor size (p=0.004) and positive estrogen receptor status (p=0.008). Patients with PIK3CA mutations showed significantly worse survival (p=0.004), particularly those with positive estrogen receptor expression or non-amplified erbB2 (both p=0.002). PIK3CA mutation was an independent factor for worse survival in breast cancer patients with non-amplified erbB2 (RR=2.6, 95%CI [1.2–5.5], p=0.016).

Keywords

AKTbreast cancererbB2estrogen receptormutationsPI3Kprognosis

Copyright information

© Springer 2005

Authors and Affiliations

  • Shao Ying Li
    • 1
  • Minna Rong
    • 1
  • Fabienne Grieu
    • 1
  • Barry Iacopetta
    • 1
    • 2
  1. 1.School of Surgery and PathologyUniversity of Western AustraliaNedlandsAustralia
  2. 2.School of Surgery and PathologyUniversity of Western Australia NedlandsAustralia