Breast Cancer Research and Treatment

, Volume 90, Issue 2, pp 113–115

Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk

  • Uwe Langsenlehner
  • Peter Krippl
  • Wilfried Renner
  • Babak Yazdani-Biuki
  • Tanja Eder
  • Herwig Köppel
  • Thomas C. Wascher
  • Bernhard Paulweber
  • Hellmut Samonigg
Report

DOI: 10.1007/s10549-004-3607-7

Cite this article as:
Langsenlehner, U., Krippl, P., Renner, W. et al. Breast Cancer Res Treat (2005) 90: 113. doi:10.1007/s10549-004-3607-7

Abstract

Interleukin-10 (IL-10) is an immunosuppressive cytokine which may facilitate development of cancer by supporting tumor escape from the immune response. A [TCATA] haplotype formed by polymorphisms at positions −3575, −2763, −1082, −819 and −592 in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the −592C > A polymorphism. Aim of the present study was to analyze the role of the IL-10 [TCATA] haplotype for breast cancer. We performed a case–control study including 500 female patients with histologically confirmed breast cancer and 500 female, age-matched, healthy control subjects from population-based screening studies. The −592C > A polymorphism was determined by a 5′-nuclease assay (TaqMan). Frequency of the homozygous −592 AA genotype, indicating homozygosity for the [TCATA] haplotype, was 4.2% among patients and 7.3% among controls (p=0.038; odds ratio 0.56; 95% confidence interval 0.32–0.97). IL-10 genotypes were not associated with tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. Therefore we conclude that the IL-10 −592C > A promoter polymorphism may be associated with a reduced breast cancer risk.

Keywords

breast cancer epidemiology genetics interleukin-10 polymorphism 

Copyright information

© Springer 2005

Authors and Affiliations

  • Uwe Langsenlehner
    • 1
  • Peter Krippl
    • 1
  • Wilfried Renner
    • 2
  • Babak Yazdani-Biuki
    • 3
  • Tanja Eder
    • 4
  • Herwig Köppel
    • 3
  • Thomas C. Wascher
    • 3
  • Bernhard Paulweber
    • 5
  • Hellmut Samonigg
    • 1
  1. 1.Department of Internal Medicine, Division of OncologyMedical University GrazGrazAustria
  2. 2.Clinical Institute of Medical and Laboratory DiagnosticsMedical University GrazAustria
  3. 3.Department of Internal MedicineMedical University GrazAustria
  4. 4.Department of RadiooncologyMedical University GrazAustria
  5. 5.Department of Internal MedicineSalzburgAustria

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