Breast Cancer Research and Treatment

, Volume 89, Issue 3, pp 309–312

HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case–control analyses

  • Robert C.  Millikan
  • Amanda J.  Hummer
  • Mary S.  Wolff
  • Asahi Hishida
  • Colin B.  Begg
Brief communication

DOI: 10.1007/s10549-004-2171-5

Cite this article as:
Millikan, R.C., Hummer, A.J., Wolff, M.S. et al. Breast Cancer Res Treat (2005) 89: 309. doi:10.1007/s10549-004-2171-5

Summary

Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case–control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.

Keywords

breast cancer genetics HER2 polymorphism 

Copyright information

© Springer 2005

Authors and Affiliations

  • Robert C.  Millikan
    • 1
  • Amanda J.  Hummer
    • 2
  • Mary S.  Wolff
    • 3
  • Asahi Hishida
    • 4
  • Colin B.  Begg
    • 2
  1. 1.Department of Epidemiology, School of Public HealthUniversity of North CarolinaChapel HillUSA
  2. 2.Memorial Sloan Kettering Cancer CenterNew YorkUSA
  3. 3.Mount Sinai Medical CenterNew YorkUSA
  4. 4.Nagoya University Graduate School of MedicineNagoyaJapan

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