, Volume 89, Issue 3, pp 309-312

HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case–control analyses

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Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case–control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.