Brain Topography

, Volume 26, Issue 3, pp 363–377

The Change of Functional Connectivity Specificity in Rats Under Various Anesthesia Levels and its Neural Origin

Original Paper

DOI: 10.1007/s10548-012-0267-5

Cite this article as:
Liu, X., Zhu, XH., Zhang, Y. et al. Brain Topogr (2013) 26: 363. doi:10.1007/s10548-012-0267-5

Abstract

Spatiotemporal correlations of spontaneous blood oxygenation level dependent (BOLD) signals measured in the resting brain have been found to imply many resting-state coherent networks under both awake/conscious and anesthetized/unconscious conditions. To understand the resting-state brain networks in the unconscious state, spontaneous BOLD signals from the rat sensorimotor cortex were studied across a wide range of anesthesia levels induced by isoflurane. Distinct resting-state networks covering functionally specific sub-regions of the sensorimotor system were observed under light anesthesia with 1.0 % isoflurane; however, they gradually merged into a highly synchronized and spatially less-specific network under deep anesthesia with 1.8 % isoflurane. The EEG power correlations recorded using three electrodes from a separate group of rats showed similar dependency on anesthesia depth, suggesting the neural origin of the change in functional connectivity specificity. The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states.

Keywords

Functional MRI (fMRI)BOLDResting-state fMRI (rs-fMRI)Functional connectivityAnesthesiaAnimal modelsNeural origin

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of Radiology, Center for Magnetic Resonance ResearchUniversity of MinnesotaMinneapoliUSA
  2. 2.Department of Biomedical EngineeringUniversity of MinnesotaMinneapoliUSA