Brain Topography

, Volume 23, Issue 4, pp 375–384

High Gamma Oscillations of Sensorimotor Cortex During Unilateral Movement in the Developing Brain: a MEG Study

Authors

    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
    • Bioelectromagnetic Lab, Institute of Electrical EngineeringChinese Academy of Sciences
  • Yingying Wang
    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
  • Rupesh Kotecha
    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
  • Elijah G. Kirtman
    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
  • Hisako Fujiwara
    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
  • Nat Hemasilpin
    • Department of Clinical EngineeringCincinnati Children’s Hospital Medical Center
  • Ton Degrauw
    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
  • Douglas F. Rose
    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
  • Jing Xiang
    • Department of Neurology, MLC 2015Cincinnati Children’s Hospital Medical Center
Original Paper

DOI: 10.1007/s10548-010-0151-0

Cite this article as:
Huo, X., Wang, Y., Kotecha, R. et al. Brain Topogr (2011) 23: 375. doi:10.1007/s10548-010-0151-0

Abstract

Recent studies in adults have found consistent contralateral high gamma activities in the sensorimotor cortex during unilateral finger movement. However, no study has reported on this same phenomenon in children. We hypothesized that contralateral high gamma activities also exist in children during unilateral finger movement. Sixty normal children (6–17 years old) were studied with a 275-channel MEG system combined with synthetic aperture magnetometry (SAM). Sixty participants displayed consistently contralateral event-related synchronization (C-ERS) within high gamma band (65–150 Hz) in the primary motor cortices (M1) of both hemispheres. Interestingly, nineteen younger children displayed ipsilateral event-related synchronization (I-ERS) within the high gamma band (65–150 Hz) just during their left finger movement. Both I-ERS and C-ERS were localized in M1. The incidence of I-ERS showed a significant decrease with age. Males had significantly higher odds of having ipsilateral activity compared to females. Noteworthy, high gamma C-ERS appeared consistently, while high gamma I-ERS changed with age. The asymmetrical patterns of neuromagnetic activities in the children’s brain might represent the maturational lateralization and/or specialization of motor function. In conclusion, the present results have demonstrated that contralateral high-gamma neuromagnetic activities are potential biomarkers for the accurate localization of the primary motor cortex in children. In addition, the interesting finding of the ipsilateral high-gamma neuromagnetic activities opens a new window for us to understand the developmental changes of the hemispherical functional lateralization in the motor system.

Keywords

Magnetoencephalography (MEG)Sensorimotor cortexEvent-related desynchronization (ERD)Event-related synchronization (ERS)Synthetic aperture magnetometry (SAM)Mirror movements (MM)

Copyright information

© Springer Science+Business Media, LLC 2010