, Volume 35, Issue 4, pp 689-693
Date: 09 Mar 2012

The clinical implementation of whole genome sequencing: a conversation with seven scientific experts

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Abstract

This commentary is based on the key note address given by Jordan Lerner-Ellis at the annual symposium of the Society for the Study of Inborn Errors of Metabolism, held in Geneva, Switzerland in August 2011. The content of the address was developed from a series of discussions with seven clinicians and medical geneticists, all having a long-time interest in genetic testing and genomic medicine (the interviews were not intended to be a forum for the introduction of new data). All participants were asked to offer their views on five questions: the benefits of using whole genome sequencing (WGS) in the clinic; the corresponding risks; the limitations on its wider use; the interviewees’ particular interests in using WGS in their practice; and projected timelines for successful adoption in clinical medicine.

Communicated by: John Christodoulou
Competing interest: None declared.
Presented at the Annual Symposium of the SSIEM, Geneva, Switzerland, August 30 - September 2, 2011.

Participants

Harvey Levy, MD, Senior Physician in Medicine/Genetics, Children’s Hospital Boston; Professor of Pediatrics, Harvard Medical School; Gerard T. Berry, MD, Division of Genetics, Children’s Hospital Boston, Harvard Medical School; David T. Miller, MD, PhD, Assistant Professor of Pediatrics, Clinical Genetics and Clinical Molecular Genetics, Harvard Medical School; Michael Murray, MD, Clinical Chief, Genetics Division, Instructor, Harvard Medical School; David Rosenblatt, MD, Chairman, Department of Human Genetics, Professor, Departments of Human Genetics, Medicine, Pediatrics, and Biology, McGill University; Heidi L. Rehm, PhD, Assistant Professor of Pathology, Brigham & Women’s Hospital and Harvard Medical School, Director, Laboratory for Molecular Medicine, Partners Healthcare Center for Personalized Genetic Medicine; Robert C. Green, MD, MPH, Associate Professor of Genetics, Harvard Medical School and Associate Director, Partners Center for Personalized Genetic Medicine.