Mitochondria and diabetes mellitus: untangling a conflictive relationship?
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- Schiff, M., Loublier, S., Coulibaly, A. et al. J Inherit Metab Dis (2009) 32: 684. doi:10.1007/s10545-009-1263-0
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Diabetes mellitus is occasionally observed in patients with skeletal muscle respiratory chain deficiency, suggesting that skeletal muscle mitochondrial dysfunction might play a pathogenic role in type 2 diabetes (T2D). In support of this hypothesis, decreased muscle mitochondrial activity has been reported in T2D patients and in mouse models of diabetes. However, recent work by several groups suggests that decreased muscle mitochondrial function may be a consequence rather than a cause of diabetes, since decreased mitochondrial function in mice affords protection from diabetes and obesity. We review the data on this controversial but important issue of potential links between mitochondrial dysfunction and diabetes.
hepatocyte nuclear factor-1α
mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes
maternally inherited diabetes and deafness syndrome
maturity-onset diabetes of the young
peroxisome proliferator-activated receptor γ co-activator 1α
peroxisome proliferator-activated receptor
type 2 diabetes
thiamine-responsive megaloblastic anaemia
uncoupling protein 2