Journal of Inherited Metabolic Disease

, Volume 31, Supplement 2, pp 329–332

d-Ribose therapy in four Polish patients with adenylosuccinate lyase deficiency: Absence of positive effect

  • A. Jurecka
  • A. Tylki-Szymanska
  • M. Zikanova
  • J. Krijt
  • S. Kmoch
Short Report

DOI: 10.1007/s10545-008-0904-z

Cite this article as:
Jurecka, A., Tylki-Szymanska, A., Zikanova, M. et al. J Inherit Metab Dis (2008) 31: 329. doi:10.1007/s10545-008-0904-z

Summary

Deficiency of adenylosuccinate lyase (ADSL) (OMIM 103050) is an autosomal recessive disorder of the purine de novo synthesis pathway and purine nucleotide cycle, diagnosed so far in approximately 50 patients. The clinical presentation is characterized by severe neurological involvement including hypotonia, seizures, developmental delay and autistic features. Epilepsy in ADSL deficiency is frequent and occurs in approximately two-thirds of patients, beginning either early in the neonatal period or after the first year of life. At present there is no treatment of proven clinical efficacy. Despite of the increasing number of ADSL-deficient patients reported, there are only a few communications of therapeutic considerations or efforts. Among them only two showed some beneficial effects in ADSL-deficient patients. d-Ribose, a simple and relatively cheap therapy, has been associated with improvement of behaviour and progressive reduction of the seizure frequency in one 13-year-old patient with ADSL deficiency. In this study we have re-examined d-ribose treatment in four ADSL-deficient patients. Assessments consisted of biochemical markers and neurological outcome. The 12-month trial of d-ribose failed to show any clinical benefit in ADSL patients with both milder and severe phenotype. d-Ribose administration was accompanied by neither reduction in seizure frequency nor growth enhancement. Additionally, patients with milder type II presented the first seizure after 4 and 8 months of the d-ribose treatment. Therefore, we could not confirm a positive effect of d-ribose as previously reported.

Abbreviations

ADSL

adenylosuccinate lyase

CMHI

Children’s Memorial Health Institute

HPLC

high-performance liquid chromatography

SAdo

succinyladenosine

SAICAr

succinylaminoimidazole carboxamide riboside

UA

uric acid

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • A. Jurecka
    • 1
  • A. Tylki-Szymanska
    • 1
  • M. Zikanova
    • 2
  • J. Krijt
    • 2
  • S. Kmoch
    • 2
  1. 1.Department of Metabolic Diseases, Endocrinology and DiabetologyThe Children’s Memorial Health InstituteWarsawPoland
  2. 2.Institute for Inherited Metabolic DisordersCharles University, 1st Faculty of MedicinePragueCzech Republic