Biomedical Microdevices

, 11:959

A passive MEMS drug delivery pump for treatment of ocular diseases

  • Ronalee Lo
  • Po-Ying Li
  • Saloomeh Saati
  • Rajat N. Agrawal
  • Mark S. Humayun
  • Ellis Meng
Article

DOI: 10.1007/s10544-009-9313-9

Cite this article as:
Lo, R., Li, P., Saati, S. et al. Biomed Microdevices (2009) 11: 959. doi:10.1007/s10544-009-9313-9

Abstract

An implantable manually-actuated drug delivery device, consisting of a refillable drug reservoir, flexible cannula, check valve, and suture tabs, was investigated as a new approach for delivering pharmaceuticals to treat chronic ocular diseases. Devices are fabricated by molding and bonding three structured layers of polydimethylsiloxane. A 30 gauge non-coring needle was used to refill the reservoir; this size maximized the number of repeated refills while minimizing damage to the reservoir. The check valve cracking pressure was 76 ± 8.5 mmHg (mean ± SE, n = 4); the valve sustained > 2000 mmHg of reverse pressure without leakage. Constant delivery at 1.57 ± 0.2 µL/sec and 0.61 ± 0.2 µL/sec (mean ± SE, n = 4) under 500 mmHg and 250 mmHg of applied pressure, respectively, was obtained in benchtop experiments. The valve closing time constant was 10.2 s for 500 mmHg and 14.2 s for 250 mmHg. Assembled devices were successfully demonstrated in benchtop, ex vivo, and in vivo experiments.

Keywords

Manual actuationDrug pumpPolydimethylsiloxaneOcular diseases

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ronalee Lo
    • 1
  • Po-Ying Li
    • 2
  • Saloomeh Saati
    • 3
  • Rajat N. Agrawal
    • 3
  • Mark S. Humayun
    • 3
  • Ellis Meng
    • 1
    • 2
  1. 1.Department of Biomedical Engineering, Viterbi School of EngineeringUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Electrical Engineering, Viterbi School of EngineeringUniversity of Southern CaliforniaLos AngelesUSA
  3. 3.Department of Ophthalmology, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA