Biomedical Microdevices

, Volume 11, Issue 4, pp 883–892

Microdevice for the isolation and enumeration of cancer cells from blood

Authors

  • Swee Jin Tan
    • Institute of MicroelectronicsA*STAR (Agency for Science, Technology and Research)
    • Graduate School for Integrative Sciences and EngineeringNational University of Singapore
  • Levent Yobas
    • Institute of MicroelectronicsA*STAR (Agency for Science, Technology and Research)
  • Gabriel Yew Hoe Lee
    • Singapore-MIT Alliance
  • Choon Nam Ong
    • Department of Epidemiology and Public HealthNational University of Singapore
    • Graduate School for Integrative Sciences and EngineeringNational University of Singapore
    • Singapore-MIT Alliance
    • Division of Bioengineering and Department of Mechanical EngineeringNational University of Singapore
Article

DOI: 10.1007/s10544-009-9305-9

Cite this article as:
Tan, S.J., Yobas, L., Lee, G.Y.H. et al. Biomed Microdevices (2009) 11: 883. doi:10.1007/s10544-009-9305-9

Abstract

Cancer metastasis is the main attribute to cancer-related deaths. Furthermore, clinical reports have shown a strong correlation between the disease development and number of circulating tumor cells (CTCs) in the peripheral blood of cancer patients. Here, we present a label-free microdevice capable of isolating cancer cells from whole blood via their distinctively different physical properties such as deformability and size. The isolation efficiency is at least 80% for tests performed on breast and colon cancer cells. Viable isolated cells are also obtained which may give further insights to the understanding of the metastatic process. Contrasting with conventional biochemical techniques, the uniqueness of this microdevice lies in the mechanistic and efficient means of isolating viable cancer cells in blood. The microdevice has the potential to be used for routine monitoring of cancer development and cancer therapy in a clinical setting.

Keywords

Circulating tumor cells (CTCs)Microfluidic deviceCancer cell isolationMetastasisPhysical separationBiomechanical propertiesCell mechanics

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC 2009