Biomedical Microdevices

, Volume 11, Issue 4, pp 843–850

Fabrication of orderly nanostructured PLGA scaffolds using anodic aluminum oxide templates

Authors

    • Department of Mechanical EngineeringNational Chung-Hsing University
    • Institute of Biomedical EngineeringNational Chung-Hsing University
  • Yan-Cheng Lin
    • Department of Mechanical EngineeringNational Chung-Hsing University
  • Ching-Wen Li
    • Department of Mechanical EngineeringNational Chung-Hsing University
    • Institute of Biomedical EngineeringNational Chung-Hsing University
  • Cheng-Chih Hsueh
    • Department of Mechanical EngineeringNational Chung-Hsing University
  • Shan-hui Hsu
    • Institute of Biomedical EngineeringNational Chung-Hsing University
    • Department of Chemical EngineeringNational Chung-Hsing University
  • Huey-Shan Hung
    • Department of Chemical EngineeringNational Chung-Hsing University
Article

DOI: 10.1007/s10544-009-9301-0

Cite this article as:
Wang, G., Lin, Y., Li, C. et al. Biomed Microdevices (2009) 11: 843. doi:10.1007/s10544-009-9301-0

Abstract

In this research, two simple fabrication methods to fabricate orderly nanostructured PLGA scaffolds using anodic aluminum oxide (AAO) template were conducted. In the vacuum air-extraction approach, the PLGA solution was cast on an AAO template first. The vacuum air-extraction process was then applied to suck the semi-congealed PLGA into the nanopores of the AAO template to form a bamboo sprouts array of PLGA. The surface roughness of the nanostructured scaffolds, ranging from 20 nm to 76 nm, can be controlled by the sucking time of the vacuum air-extraction process. In the replica molding approach, the PLGA solution was cast on the orderly scraggy barrier-layer surface of an AAO membrane to fabricate a PLGA scaffold of concave nanostructure. Cell culture experiments using the bovine endothelial cells (BEC) demonstrated that the nanostructured PLGA membrane can increase the cell growing rate, especially for the bamboo sprouts array scaffolds with smaller surface roughness.

Keywords

Orderly nanostructured PLGA scaffoldAAO templateVacuum air-extractionReplica moldingBovine endothelial cells

Copyright information

© Springer Science+Business Media, LLC 2009