Biomedical Microdevices

, 10:785

Iron-oxide embedded solid lipid nanoparticles for magnetically controlled heating and drug delivery

Authors

  • Ming-Huang Hsu
    • Department of Engineering and System ScienceNational Tsing Hua University
    • Department of Engineering and System ScienceNational Tsing Hua University
Article

DOI: 10.1007/s10544-008-9192-5

Cite this article as:
Hsu, M. & Su, Y. Biomed Microdevices (2008) 10: 785. doi:10.1007/s10544-008-9192-5

Abstract

This paper presents the development of magnetic lipid nanoparticles that could serve as controlled delivery vehicles for releasing encapsulated drugs in a desired manner. The nanoparticles are composed of multiple drugs in lipid matrices, which are solid at body temperature and melt around 45°C to 55°C. In addition, super-paramagnetic γ-Fe2O3 particles with sizes ranging from 5 to 25 nm are surface modified and dispersed uniformly in the lipid nanoparticles. In the prototype demonstration, lipid nanoparticles with average sizes between 100 and 180 nm were fabricated by high-pressure homogenization at elevated temperatures. When exposed to an alternating magnetic field of 60 kA/m at 25 kHz, a solution containing 2 g/L encapsulated γ-Fe2O3 particles showed a temperature increase from 37°C to 50°C in 20 min. Meanwhile, the dissipated heat melted the surrounding lipid matrices and resulted in an accelerated release of the encapsulated drugs. Within 20 min, approximately 35% of the encapsulated drug molecules were released from the lipid nanoparticles through diffusion. As such, the presented lipid nanoparticles enable a new scheme that combines magnetic control of heating and drug delivery, which could greatly enhance the performance of encapsulated drugs.

Keywords

Drug delivery Hyperthermia Nanoparticles Solid lipid nanoparticles Homogenization Magnetic heating Controlled release

Copyright information

© Springer Science+Business Media, LLC 2008