Biomedical Microdevices

, Volume 7, Issue 3, pp 247–251

Detecting Common Gene Expression Patterns in Multiple Cancer Outcome Entities

Article

DOI: 10.1007/s10544-005-3032-7

Cite this article as:
Yang, X., Bentink, S. & Spang, R. Biomed Microdevices (2005) 7: 247. doi:10.1007/s10544-005-3032-7

Abstract

Most oncological microarray studies focus on molecular distinctions in different cancer entities. Recently, researchers started using microarrays for investigating molecular commonalities of multiple cancer types. This poses novel bioinformatics challenges.

In this paper we describe a method that detects common molecular mechanisms in different cancer entities. The method extends previously described concepts by introducing Meta-Analysis Pattern Matches. In an analysis of four prognostic cancer studies, involving breast cancer, leukemia, and mesothelioma, we are able to identify 42 genes that show consistent up- or down-regulation in patients with a poor disease outcome. These genes complement the set of previously published candidates for universal prognostic markers in cancer.

Keywords

molecular cancer mechanismsmeta-analysiscomputational diagnosticsmicroarraysbioinformatics

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Computational Diagnostics Group, Department of Computational Molecular BiologyMPI for Molecular GeneticsBerlinGermany
  2. 2.State Key Laboratory of BioelectronicsSoutheast UniversityNanjingP. R. China