Biomedical Microdevices

, Volume 7, Issue 3, pp 185–188

Sugar Micro Needles as Transdermic Drug Delivery System

  • Takaya Miyano
  • Yoshikazu Tobinaga
  • Takahiro Kanno
  • Yasushi Matsuzaki
  • Hitoshi Takeda
  • Makoto Wakui
  • Katsumi Hanada
Article

DOI: 10.1007/s10544-005-3024-7

Cite this article as:
Miyano, T., Tobinaga, Y., Kanno, T. et al. Biomed Microdevices (2005) 7: 185. doi:10.1007/s10544-005-3024-7

Abstract

We designed and fabricated an array of sugar micro needles of the length ranging from 150 μ m to 2 mm for transdermic delivery of drugs. Micro needles were molded out of maltose mixed with pharmaceutical material, being expected bio-degradable in the human skin. To test basic tolerance to the healthy human skin, a clinical experiment was carried out for 10 healthy adult volunteers. 500 μ m-needles containing 5 wt% of ascorbate-2-glycoside were inserted into the skin of the forearm and snapped off to be left in the skin. They spontaneously dissolved by hydrolysis to release ascorbate in the epidermis and the dermis. No dermatological problems were observed in terms of the International Contact Dermatitis Research Group criteria. These observations indicate that the present system is a novel approach to achieve transdermic drug delivery.

Keywords

drug delivery systemmicro needlebio-degradabletransdermicsugars

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Takaya Miyano
    • 1
  • Yoshikazu Tobinaga
    • 2
  • Takahiro Kanno
    • 3
  • Yasushi Matsuzaki
    • 4
  • Hitoshi Takeda
    • 4
  • Makoto Wakui
    • 3
  • Katsumi Hanada
    • 1
  1. 1.Department of Micro System TechnologyRitsumeikan UniversityKusatsuJapan
  2. 2.Nano Device and System Research IncorporationShimogyo-kuJapan
  3. 3.Department of PhysiologyHirosaki University School of MedicineHirosakiJapan
  4. 4.Department of DermatologyHirosaki University School of MedicineHirosakiJapan