BioMetals

, Volume 28, Issue 2, pp 231–254

Mercury and metabolic syndrome: a review of experimental and clinical observations

  • Alexey A. Tinkov
  • Olga P. Ajsuvakova
  • Margarita G. Skalnaya
  • Elizaveta V. Popova
  • Anton I. Sinitskii
  • Olga N. Nemereshina
  • Evgenia R. Gatiatulina
  • Alexandr A. Nikonorov
  • Anatoly V. Skalny
Article

DOI: 10.1007/s10534-015-9823-2

Cite this article as:
Tinkov, A.A., Ajsuvakova, O.P., Skalnaya, M.G. et al. Biometals (2015) 28: 231. doi:10.1007/s10534-015-9823-2

Abstract

A significant interrelation between heavy metal exposure and metabolic syndrome (MetS) development has been demonstrated earlier. Despite the presence of a number of works aimed at the investigation of the role of Hg in MetS development, the existing data remain contradictory. Therefore, the primary objective of the current work is to review the existing data regarding the influence of mercury on universal mechanisms involved in the pathogenesis of the development of MetS and its components. The brief chemical characterization of mercury is provided. The role of mercury in induction of oxidative stress has been discussed. In particular, Hg-induced oxidative stress may occur due to both prooxidant action of the metal and decrease in antioxidant enzymes. Despite the absence of direct indications, it can be proposed that mercury may induce endoplasmic reticulum stress. As it is seen from both in vivo and in vitro studies, mercury is capable of inducing inflammation. The reviewed data demonstrate that mercury affects universal pathogenetic mechanisms of MetS development. Moreover, multiple investigations have indicated the role of mercury in pathogenesis of MetS components: dyslipidemia, hypertension, insulin resistance, and obesity to a lesser extent. The present state of data regarding the interrelation between mercury and MetS denotes the following perspectives: (1) Further clinic-epidemiologic and experimental studies are required to estimate the association between mercury exposure and the development of MetS components, especially obesity; (2) Additional investigations of the possible effect of organism’s mercury content modulation on MetS pathogenesis should be undertaken.

Keywords

Mercury Toxicity Obesity Insulin resistance Hypertension Dyslipidemia Atherosclerosis 

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Alexey A. Tinkov
    • 1
    • 2
  • Olga P. Ajsuvakova
    • 3
    • 4
  • Margarita G. Skalnaya
    • 5
  • Elizaveta V. Popova
    • 2
  • Anton I. Sinitskii
    • 6
  • Olga N. Nemereshina
    • 2
  • Evgenia R. Gatiatulina
    • 2
  • Alexandr A. Nikonorov
    • 2
  • Anatoly V. Skalny
    • 1
    • 5
    • 7
  1. 1.Laboratory of Biotechnology and Applied BioelementologyYaroslavl State UniversityYaroslavlRussia
  2. 2.Department of BiochemistryOrenburg State Medical AcademyOrenburgRussia
  3. 3.Department of ChemistryOrenburg State Agrarian UniversityOrenburgRussia
  4. 4.Department of Chemistry and Methods of Chemistry TeachingOrenburg State Pedagogical UniversityOrenburgRussia
  5. 5.Russian Society of Trace Elements in MedicineANO “Centre for Biotic Medicine”MoscowRussia
  6. 6.Department of Chemistry of the Pharmaceutical FacultySouth Ural State Medical UniversityChelyabinskRussia
  7. 7.Institute of Bioelementology (Russian Satellite Centre of Trace Element—Institute for UNESCO)Orenburg State UniversityOrenburgRussia