, Volume 24, Issue 6, pp 1093–1098

Metal chelation therapy in rheumathoid arthritis: a case report

Successful management of rheumathoid arthritis by metal chelation therapy
  • Fabrizia Bamonti
  • Alessandro Fulgenzi
  • Cristina Novembrino
  • Maria Elena Ferrero

DOI: 10.1007/s10534-011-9467-9

Cite this article as:
Bamonti, F., Fulgenzi, A., Novembrino, C. et al. Biometals (2011) 24: 1093. doi:10.1007/s10534-011-9467-9


Toxic metals are involved in the pathogenesis of some neurodegenerative and vascular diseases and are known to impair the immune system functions. We report here the case of a patient affected by heavy metal intoxication, who had developed an autoimmune disease. There was evidence of aluminium, cadmium and lead intoxication in a 63-year old Italian woman affected by rheumatoid arthritis (RA). We treated the patient with calcium disodium edetate (EDTA) once a week for a year in order to remove traces of heavy metal intoxication. Oxidative status profile was carried out at the beginning and after 6 months’ EDTA chelation. At the end of the treatment, the patient did not show any signs of metal intoxication, RA symptoms and oxidative status improved.


Chelation therapyRheumathoid arthritisEDTAMetal intoxication



Calcium disodium edetate


Reactive oxygen species


Reduced form of glutathione


Oxidized form of glutathione


Total antioxidant capacity

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Fabrizia Bamonti
    • 1
  • Alessandro Fulgenzi
    • 2
  • Cristina Novembrino
    • 1
  • Maria Elena Ferrero
    • 2
  1. 1.Dipartimento di Scienze MedicheUniversità di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina ElenaMilanItaly
  2. 2.Dipartimento di Morfologia Umana e Scienze Biomediche Città StudiUniversità di MilanoMilanItaly