Article

BioMetals

, Volume 24, Issue 6, pp 1093-1098

First online:

Metal chelation therapy in rheumathoid arthritis: a case report

Successful management of rheumathoid arthritis by metal chelation therapy
  • Fabrizia BamontiAffiliated withDipartimento di Scienze Mediche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena
  • , Alessandro FulgenziAffiliated withDipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Università di Milano
  • , Cristina NovembrinoAffiliated withDipartimento di Scienze Mediche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena
  • , Maria Elena FerreroAffiliated withDipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Università di Milano Email author 

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Abstract

Toxic metals are involved in the pathogenesis of some neurodegenerative and vascular diseases and are known to impair the immune system functions. We report here the case of a patient affected by heavy metal intoxication, who had developed an autoimmune disease. There was evidence of aluminium, cadmium and lead intoxication in a 63-year old Italian woman affected by rheumatoid arthritis (RA). We treated the patient with calcium disodium edetate (EDTA) once a week for a year in order to remove traces of heavy metal intoxication. Oxidative status profile was carried out at the beginning and after 6 months’ EDTA chelation. At the end of the treatment, the patient did not show any signs of metal intoxication, RA symptoms and oxidative status improved.

Keywords

Chelation therapy Rheumathoid arthritis EDTA Metal intoxication