BioMetals

, Volume 22, Issue 4, pp 691–695

Salmochelin, the long-overlooked catecholate siderophore of Salmonella

  • Silke I. Müller
  • Marianne Valdebenito
  • Klaus Hantke
Article

DOI: 10.1007/s10534-009-9217-4

Cite this article as:
Müller, S.I., Valdebenito, M. & Hantke, K. Biometals (2009) 22: 691. doi:10.1007/s10534-009-9217-4

Abstract

Salmochelin is a C-glucosylated enterobactin produced by Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. It was the first glucosylated siderophore described. The glucosylation has been interpreted as a bacterial evasion mechanism against the mammalian catecholate siderophore-binding protein siderocalin (NGAL-lipocalin). The synthesis, excretion, and uptake of salmochelin requires five genes, iroBCDEN, and also the enterobactin biosynthesis and utilization system. Some salmochelin-producing strains also secrete microcins, which possess a C-terminal, linear glucosyl-enterobactin moiety. These microcins recognize the catecholate siderophore receptors IroN, Cir, Fiu, and FepA, and may inhibit the growth of competitors for catecholate siderophores.

Keywords

SalmochelinIron transportSiderocalinSalmonellaC-glucosylationMicrocin E492

Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Silke I. Müller
    • 1
  • Marianne Valdebenito
    • 1
  • Klaus Hantke
    • 1
  1. 1.Lehrstuhl für Mikrobiologie – Organismische InteraktionenUniversität TübingenTübingenGermany