Article

BioMetals

, Volume 22, Issue 4, pp 691-695

First online:

Salmochelin, the long-overlooked catecholate siderophore of Salmonella

  • Silke I. MüllerAffiliated withLehrstuhl für Mikrobiologie – Organismische Interaktionen, Universität Tübingen
  • , Marianne ValdebenitoAffiliated withLehrstuhl für Mikrobiologie – Organismische Interaktionen, Universität Tübingen
  • , Klaus HantkeAffiliated withLehrstuhl für Mikrobiologie – Organismische Interaktionen, Universität Tübingen Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Salmochelin is a C-glucosylated enterobactin produced by Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. It was the first glucosylated siderophore described. The glucosylation has been interpreted as a bacterial evasion mechanism against the mammalian catecholate siderophore-binding protein siderocalin (NGAL-lipocalin). The synthesis, excretion, and uptake of salmochelin requires five genes, iroBCDEN, and also the enterobactin biosynthesis and utilization system. Some salmochelin-producing strains also secrete microcins, which possess a C-terminal, linear glucosyl-enterobactin moiety. These microcins recognize the catecholate siderophore receptors IroN, Cir, Fiu, and FepA, and may inhibit the growth of competitors for catecholate siderophores.

Keywords

Salmochelin Iron transport Siderocalin Salmonella C-glucosylation Microcin E492