BioMetals

, Volume 21, Issue 3, pp 273–276

Non-transferrin-bound iron in plasma following administration of oral iron drugs

Authors

  • Bernd Dresow
    • Inst. für Biochemie und Molekularbiologie II: Molekulare ZellbiologieZentrum für Experimentelle Medizin Universitätsklinikum Hamburg-Eppendorf
  • Doerte Petersen
    • Inst. für Biochemie und Molekularbiologie II: Molekulare ZellbiologieZentrum für Experimentelle Medizin Universitätsklinikum Hamburg-Eppendorf
  • Roland Fischer
    • Inst. für Biochemie und Molekularbiologie II: Molekulare ZellbiologieZentrum für Experimentelle Medizin Universitätsklinikum Hamburg-Eppendorf
    • Inst. für Biochemie und Molekularbiologie II: Molekulare ZellbiologieZentrum für Experimentelle Medizin Universitätsklinikum Hamburg-Eppendorf
Article

DOI: 10.1007/s10534-007-9116-5

Cite this article as:
Dresow, B., Petersen, D., Fischer, R. et al. Biometals (2008) 21: 273. doi:10.1007/s10534-007-9116-5

Abstract

Non-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with normal iron stores or from patients with iron deficiency anaemia after oral application of pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up to 9 μM were found within the time period of 1–4 h after administration whereas transferrin saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but still measurable NTBI values. The physiological relevance of this finding for patients under iron medication has to be elucidated.

Keywords

Non-transferrin-bound iron—NTBIOral iron drugsTransferrin saturationIron medicationRisk factor

Copyright information

© Springer Science+Business Media, LLC. 2007