Non-transferrin-bound iron in plasma following administration of oral iron drugs
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- Dresow, B., Petersen, D., Fischer, R. et al. Biometals (2008) 21: 273. doi:10.1007/s10534-007-9116-5
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Non-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with normal iron stores or from patients with iron deficiency anaemia after oral application of pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up to 9 μM were found within the time period of 1–4 h after administration whereas transferrin saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but still measurable NTBI values. The physiological relevance of this finding for patients under iron medication has to be elucidated.