Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria
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- Gebhardt, P., Crumbliss, A.L., Miller, M.J. et al. Biometals (2008) 21: 41. doi:10.1007/s10534-007-9091-x
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Siderophores based on sugar backbones substituted at the 2,3,4- or 2,3,6 positions with hydroxamic or retro-hydroxamic acid chelating units were synthesized and characterized. The alkyl terminus of the iron-coordinating side chain units facilitate lipophilic interactions. Iron coordination properties and complex stability were investigated by ESI-MS and the CAS-Test. The results were correlated to structure activity relationships determined by microbial growth promotion studies under iron limited conditions using wild type strains and iron transport mutants of Mycobacterium smegmatis.