Biometals

, Volume 19, Issue 2, pp 173–180

Iron and Pathogenesis of Shigella: Iron Acquisition in the Intracellular Environment

Authors

    • Section of Molecular Genetics and MicrobiologyThe University of Texas at Austin
  • Elizabeth E. Wyckoff
    • Section of Molecular Genetics and MicrobiologyThe University of Texas at Austin
  • Erin R. Murphy
    • Section of Molecular Genetics and MicrobiologyThe University of Texas at Austin
  • Amanda G. Oglesby
    • Section of Molecular Genetics and MicrobiologyThe University of Texas at Austin
  • Megan L. Boulette
    • Section of Molecular Genetics and MicrobiologyThe University of Texas at Austin
  • Nicola M. L. Davies
    • Section of Molecular Genetics and MicrobiologyThe University of Texas at Austin
Article

DOI: 10.1007/s10534-005-4577-x

Cite this article as:
Payne, S.M., Wyckoff, E.E., Murphy, E.R. et al. Biometals (2006) 19: 173. doi:10.1007/s10534-005-4577-x

Abstract

Shigella species are able to grow in a variety of environments, including intracellularly in host epithelial cells. Shigella have a number of different iron transport systems that contribute to their ability to grow in these diverse environments. Siderophore iron uptake systems, heme transporters, and ferric and ferrous iron transport systems are present in these bacteria, and the genes encoding some of these systems appear to have spread among the Shigella species by horizontal transmission. Iron is not only essential for growth of Shigella but also plays an important role in regulation of metabolic processes and virulence determinants in Shigella. This regulation is mediated by the repressor protein Fur and the small RNA RyhB.

Keywords

ShigellasiderophoreFurFeoSitaerobactinRyhBvirulence
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Copyright information

© Springer 2006