, Volume 36, Issue 6, pp 1335-1341
Date: 23 Feb 2014

The subtype CD200-positive, chorionic mesenchymal stem cells from the placenta promote regeneration of human hepatocytes

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Abstract

Human placental mesenchymal stem cells (hPMSCs), for the treatment of fulminant hepatic failure, have been widely studied. Only a few studies have investigated the effect of the subtype CD200+hPMSCs on regeneration of human hepatocytes. CD200+hPMSCs can down-regulate activity of several immunocytes and suppress TNF-α secretion from macrophages via the CD200-CD200R axis. We have investigated the influence of CD200-positive human placenta chorionic mesenchymal stem cells (CD200+hPCMSCs) on metabolism, proliferation and apoptosis of human hepatocytes in vitro. CD200+hPCMSCs promote urea synthesis, albumin secretion and hepatocytes proliferation at co-culture ratios of 1:1 and 3:1. Additionally, CD200+hPCMSCs inhibit hepatocyte apoptosis via up-regulation of an anti-apoptotic protein, Bcl-xL. Thus, CD200+hPCMSCs can provide supportive benefit for the regeneration of human hepatocytes and also have immunosuppressive properties. Therefore, CD200+hPCMSCs may be an ideal candidate for stem cell-based therapy in hepatic failure.

Jian Wang and Zhengyan Zhu contributed equally to this work.