Biotechnology Letters

, 33:1705

Recent advances in understanding the structure, function, and biotechnological usefulness of the hemoglobin from the bacterium Vitreoscilla

  • Benjamin C. Stark
  • Kanak L. Dikshit
  • Krishna R. Pagilla
Review

DOI: 10.1007/s10529-011-0621-9

Cite this article as:
Stark, B.C., Dikshit, K.L. & Pagilla, K.R. Biotechnol Lett (2011) 33: 1705. doi:10.1007/s10529-011-0621-9

Abstract

The hemoglobin from the bacterium Vitreoscilla (VHb) is the first microbial hemoglobin that was conclusively identified as such (in 1986). It has been extensively studied with respect to its ligand binding properties and mechanisms, structure, biochemical functions, and the mechanisms by which its expression is controlled. In addition, cloning of its gene (vgb) into a variety of heterologous hosts has proved that its expression results substantial increases in production of a variety of useful products and ability to degrade potentially harmful compounds. Recent studies (since 2005) have added significant knowledge to all of these areas and shown the broad range of biotechnological applications in which VHb can have a positive effect.

Keywords

Bioremediation enhancementEnhancement of bioproduct productionOxygen binding and deliveryOxygen sensingVitreoscilla hemoglobin

Abbreviations

CaMV

Caulifower mosaic virus

Crp

Catabolite repressor transcription regulator

2-CBA

2-Chlorobenzoic acid

2,4-DNT

2,4-Dinitrotoluene

Fnr

Fumarate nitrate reductase transcription regulator

Hb

Hemoglobin

VHb

Vitreoscilla hemoglobin

Vgb

Vitreoscilla hemoglobin gene

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Benjamin C. Stark
    • 1
  • Kanak L. Dikshit
    • 2
  • Krishna R. Pagilla
    • 3
  1. 1.Biology Division, Department of Biological, Chemical, and Physical SciencesIllinois Institute of TechnologyChicagoUSA
  2. 2.Institute of Microbial TechnologyChandigarhIndia
  3. 3.Department of Civil, Architectural, and Environmental EngineeringIllinois Institute of TechnologyChicagoUSA