Biotechnology Letters

, Volume 28, Issue 23, pp 1877–1888

IgE binding to proteins from sesame and assessment of allergenicity: implications for biotechnology?

Review

DOI: 10.1007/s10529-006-9180-x

Cite this article as:
Orruño, E. & Morgan, M.R.A. Biotechnol Lett (2006) 28: 1877. doi:10.1007/s10529-006-9180-x

Abstract

Successful prediction of the potential allergenicity of a protein may be a key factor in the development of novel, genetically modified foods. The use of the decision tree approach for the prediction of allergenicity is discussed. The methods currently used for identifying allergenic proteins (including use of IgE from patient sera for recognition of proteins) are reviewed. Finally, a specific review of the literature concerning identification of allergens from sesame leads to the conclusion that in the absence of validated animal models, identification of allergenicity (and, consequently, prediction of allergenicity) may be problematic.

Keywords

Food allergy Identification of food allergens IgE-binding proteins Prediction of allergenicity Safety of GM foods Sesame allergens Sesame allergy 

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  1. 1.Procter Department of Food ScienceUniversity of LeedsLeedsUK

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