Biotechnology Letters

, Volume 28, Issue 21, pp 1701–1712

Bacterial alginates: from biosynthesis to applications

Review

DOI: 10.1007/s10529-006-9156-x

Cite this article as:
Remminghorst, U. & Rehm, B.H.A. Biotechnol Lett (2006) 28: 1701. doi:10.1007/s10529-006-9156-x

Abstract

Alginate is a polysaccharide belonging to the family of linear (unbranched), non-repeating copolymers, consisting of variable amounts of β-d-mannuronic acid and its C5-epimer α- l-guluronic acid linked via β-1,4-glycosidic bonds. Like DNA, alginate is a negatively charged polymer, imparting material properties ranging from viscous solutions to gel-like structures in the presence of divalent cations. Bacterial alginates are synthesized by only two bacterial genera, Pseudomonas and Azotobacter, and have been extensively studied over the last 40 years. While primarily synthesized in form of polymannuronic acid, alginate undergoes chemical modifications comprising acetylation and epimerization, which occurs during periplasmic transfer and before final export through the outer membrane. Alginate with its unique material properties and characteristics has been increasingly considered as biomaterial for medical applications. The genetic modification of alginate producing microorganisms could enable biotechnological production of new alginates with unique, tailor-made properties, suitable for medical and industrial applications.

Keywords

alginatealginate polymerisationalginate secretionAzotobacterbiomaterialbiopolymerguluronic acidmannuronic acidPseudomonas

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  1. 1.Institute of Molecular BioSciencesMassey UniversityPalmerston NorthNew Zealand