Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase
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- Chidananda, C., Rao, L.J.M. & Sattur, A.P. Biotechnol Lett (2006) 28: 1633. doi:10.1007/s10529-006-9133-4
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Aldose reductase, the first key enzyme in the polyol pathway, is involved in complications of diabetes. Sclerotiorin, isolated and purified from the fermented broth of Penicillium frequentans, inhibited aldose reductase with an IC50 0.4 µM. The inhibitor also showed antibacterial activity against Bacillus spp.