Biotechnology Letters

, Volume 28, Issue 11, pp 837–841

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum

Original paper

DOI: 10.1007/s10529-006-9007-9

Cite this article as:
Li, Y. & Wang, S. Biotechnol Lett (2006) 28: 837. doi:10.1007/s10529-006-9007-9

Abstract

Ganoderic acid, from Ganoderma lucidum, at 8 µg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg·d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).

Keywords

Ganoderic acidGanoderma lucidumHepatitisHepatoprotectionVirus

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  1. 1.College of Life ScienceSouth China Normal UniversityGuangzhouP.R. China
  2. 2.Jiangxi Academy of ScienceNanchangP.R. China