, Volume 28, Issue 11, pp 837-841
Date: 31 May 2006

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum

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Abstract

Ganoderic acid, from Ganoderma lucidum, at 8 µg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg·d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).