Biotechnology Letters

, Volume 27, Issue 7, pp 483–487

Anti-diabetic activity of β-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei

  • Yea-Woon Kim
  • Ki-Hoon Kim
  • Hyun-Ju Choi
  • Dong-Seok Lee
Article

DOI: 10.1007/s10529-005-2225-8

Cite this article as:
Kim, YW., Kim, KH., Choi, HJ. et al. Biotechnol Lett (2005) 27: 483. doi:10.1007/s10529-005-2225-8

Abstract

β-Glucans were prepared from Agaricus blazei Murill by repeated extraction with hot water. The average molecular weights of β-glucans were 30–50 kDa by gel filtration chromatography. Oligosaccharides (AO), derived from hydrolyzing β-glucans with an endo-β-(1→6)-glucanase from Bacillus megaterium, were mainly di- and tri-saccharides. Though β-glucans and AO both showed anti-hyperglycemic, anti-hypertriglyceridemic, anti-hypercholesterolemic, and anti-arteriosclerotic activity indicating overall anti-diabetic activity in diabetic rats, AO had about twice the activity of β-glucans with respect to anti-diabetic activity.

Keywords

Agaricus blazei anti-diabetic activity β-glucans oligosaccharides 

Copyright information

© Springer 2005

Authors and Affiliations

  • Yea-Woon Kim
    • 1
  • Ki-Hoon Kim
    • 1
  • Hyun-Ju Choi
    • 1
  • Dong-Seok Lee
    • 1
  1. 1.Department of Biomedical Laboratory Science and Biohealth Products Research CenterInje UniversityGimhaeRepublic of Korea