Biotechnology Letters

, Volume 27, Issue 19, pp 1487–1490

Rosin Nanoparticles as a Drug Delivery Carrier for the Controlled Release of Hydrocortisone

  • Chang-Moon Lee
  • Seung Lim
  • Gwang-Yun Kim
  • Dong-Woon Kim
  • Joon Haeng Rhee
  • Ki-Young Lee
Article

DOI: 10.1007/s10529-005-1316-x

Cite this article as:
Lee, C., Lim, S., Kim, G. et al. Biotechnol Lett (2005) 27: 1487. doi:10.1007/s10529-005-1316-x

Abstract

Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167–332 nm diam. The drug was loaded approximately 50% of initial feeding amount in all formulation. Release of hydrocortisone from the nanoparticles in vitro gradually decreased with increasing initial rosin content at pH 7.4. HC was also released very slowly at pH 1.2. Nanoparticles based on rosin thus are potentially useful as a drug delivery system.

Keywords

drug releasehydrocortisonenanoparticlerosin gum

Copyright information

© Springer 2005

Authors and Affiliations

  • Chang-Moon Lee
    • 1
  • Seung Lim
    • 2
  • Gwang-Yun Kim
    • 2
  • Dong-Woon Kim
    • 3
  • Joon Haeng Rhee
    • 4
  • Ki-Young Lee
    • 5
  1. 1.Interdisciplinary Program of Biomedical EngineeringChonnam National UniversityGwangjuSouth Korea
  2. 2.Ecobio Inc., Business Incubation CenterChonnam National UniversityGwangjuSouth Korea
  3. 3.Department of Clinical PathologyGwang-Yang Health CollegeJeonnamSouth Korea
  4. 4.Department of MicrobiologyChonnam National University Medical SchoolGwangjuSouth Korea
  5. 5.Department of Applied Chemical Engineering & The Research Institute for CatalysisChonnam National UniversityGwangjuSouth Korea