Biotechnology Letters

, Volume 27, Issue 4, pp 253–257

A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin

  • Hee Jung Ji
  • Hee Kyoung Yeo
  • Nam Hee Lee
  • Jung Suk Hwang
  • Kyung Ah Koo
  • Seon Woo Cheong
  • Joo Hung Park
  • Gap Soo Oh
  • Chun Sik Yoon
  • Hyun Joo Youn
Article

DOI: 10.1007/s10529-004-8294-2

Cite this article as:
Ji, H.J., Yeo, H.K., Lee, N.H. et al. Biotechnol Lett (2005) 27: 253. doi:10.1007/s10529-004-8294-2

Abstract

Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.

Keywords

apoptosis Artemisia dioxin Fas thymotoxicity 

Copyright information

© Springer 2005

Authors and Affiliations

  • Hee Jung Ji
    • 1
  • Hee Kyoung Yeo
    • 1
  • Nam Hee Lee
    • 1
  • Jung Suk Hwang
    • 1
  • Kyung Ah Koo
    • 1
  • Seon Woo Cheong
    • 2
  • Joo Hung Park
    • 2
  • Gap Soo Oh
    • 2
  • Chun Sik Yoon
    • 2
  • Hyun Joo Youn
    • 1
  1. 1.Department of MicrobiologySchool of Biotechnology & Biomedical Science and Bio-Health Product Research Center, Inje UniversityGimhaeS. Korea
  2. 2.Department of Biology, College of Natural SciencesChangwon National UniversityChangwonS. Korea