A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo- p-dioxin Article Received: 13 October 2004 Accepted: 13 December 2004 DOI:
Cite this article as: Ji, H.J., Yeo, H.K., Lee, N.H. et al. Biotechnol Lett (2005) 27: 253. doi:10.1007/s10529-004-8294-2 Abstract
Apoptotic death of mouse thymocytes
in vitro, as induced by 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.
Keywords apoptosis Artemisia dioxin Fas thymotoxicity
Revisions requested 29 October 2004; Revisions received 10 December 2004
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