Biochemical Genetics

, Volume 51, Issue 9, pp 780–788

Prevalence of MTHFR C677T Single Nucleotide Polymorphism in Genetically Isolated Populations in Jordan

Authors

    • Department of Biology and BiotechnologyHashemite University
  • Raja Fathallah
    • National Center for DiabetesGenetics and Endocrinology
  • Ala Arafat
    • National Center for DiabetesGenetics and Endocrinology
  • Mohammed Emad AbdulQader
    • Faculty of MedicineHashemite University
  • Nancy Hakooz
    • Department of Biopharmaceutics and Clinical Pharmacy, College of PharmacyUniversity of Jordan
  • Yousef Al-Motassem
    • Department of Biopharmaceutics and Clinical Pharmacy, College of PharmacyUniversity of Jordan
  • Mohammad El-Khateeb
    • National Center for DiabetesGenetics and Endocrinology
Article

DOI: 10.1007/s10528-013-9606-9

Cite this article as:
Dajani, R., Fathallah, R., Arafat, A. et al. Biochem Genet (2013) 51: 780. doi:10.1007/s10528-013-9606-9

Abstract

Methylenetetrahydrofolate reductase (MTHFR) C677T single nucleotide polymorphism is a major inherited risk factor of venous thromboembolism. We sought to determine its prevalence in genetically isolated populations of Chechens and Circassians in Jordan. The MTHFR C677T mutation was analyzed from blood samples taken from 120 random unrelated Chechens and 72 Circassians. The prevalence of the MTHFR mutation in the Chechen population was 27.5% (allele frequency 15%); the prevalence among the Circassians was 50% (allele frequency 29.2%). The prevalence in the Chechen population is similar to that in Jordan and other world populations, but it is higher in the Circassian population. This study will contribute to understanding the interaction between genetic and environmental risk factors underlying thrombosis and will be useful in deciding which genetic variants should be tested in a clinical genetic testing service.

Keywords

Venous thrombophiliaPrevalenceMTHFRChechenCircassian

Copyright information

© Springer Science+Business Media New York 2013