Biochemical Genetics

, Volume 50, Issue 9, pp 784–796

A 45-bp Insertion/Deletion Polymorphism in Uncoupling Protein 2 is Not Associated with Obesity in a Chinese Population

  • Xiaoqiu Liu
  • Bin Zhang
  • Xin Liu
  • Yue Shen
  • Jiana Li
  • Nan Zhao
  • Lina Ma
  • Qingmao Du
  • Lisheng Liu
  • Jingbo Zhao
  • Xingyu Wang
Article

DOI: 10.1007/s10528-012-9520-6

Cite this article as:
Liu, X., Zhang, B., Liu, X. et al. Biochem Genet (2012) 50: 784. doi:10.1007/s10528-012-9520-6

Abstract

The association of a 45-bp insertion/deletion (UCP2-45 bp I/D) polymorphism in uncoupling protein 2 with body mass index (BMI) remains controversial. A case–control study was conducted to examine the association in a Chinese population. The 1,526 subjects recruited in downtown Beijing and genotyped included 616 obese subjects with BMI >28 and 910 age- and gender-matched controls with BMI <24. The association of the polymorphisms with obesity was estimated using multivariate logistic regression in three models of inheritance. The odds ratios were 1.08 (95 % CI 0.846–1.368; P = 0.551) in the dominant model, 0.931 (0.751–1.154; P = 0.513) in the additive model, and 1.18 (0.550–2.550; P = 0.666) in the recessive model. The overall comparison of the genotype distributions in obese and control subjects using the chi-square test yielded P = 0.801. Our study demonstrated no association between UCP2-45 bp I/D and BMI variation in the Chinese population.

Keywords

UCP2PolymorphismObeseChinese populationCase–control study

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Xiaoqiu Liu
    • 1
    • 2
  • Bin Zhang
    • 3
  • Xin Liu
    • 2
  • Yue Shen
    • 2
  • Jiana Li
    • 1
    • 2
  • Nan Zhao
    • 1
    • 2
  • Lina Ma
    • 4
  • Qingmao Du
    • 3
  • Lisheng Liu
    • 2
  • Jingbo Zhao
    • 1
  • Xingyu Wang
    • 2
  1. 1.Department of Epidemiology, Public Health SchoolHarbin Medical UniversityHarbinChina
  2. 2.Laboratory of Human GeneticsBeijing Hypertension League InstituteBeijingChina
  3. 3.Yong Qing People’s HospitalLangfangChina
  4. 4.Wine Research Centre/Michael Smith Laboratories, Faculty of Land and Food SystemsUniversity of British ColumbiaVancouverCanada