Biochemical Genetics

, Volume 50, Issue 3, pp 298–308

Association of Hepatocyte Nuclear Factor 4 Alpha Polymorphisms with Type 2 Diabetes With or Without Metabolic Syndrome in Malaysia

Authors

    • Department of Molecular Medicine, Faculty of MedicineUniversity of Malaya
    • Faculty of MedicineSana’a University
  • Roslan Harun
    • UKM Medical CenterUniversity Kebangsaan Malaysia
    • UKM Medical Molecular Biology Institute (UMBI)University Kebangsaan Malaysia
  • Nor Azmi Kamaruddin
    • UKM Medical CenterUniversity Kebangsaan Malaysia
  • Saad Al-Jassabi
    • Institute of Biological ScienceUniversity of Malaya
  • Wan Zurinah Wan Ngah
    • UKM Medical CenterUniversity Kebangsaan Malaysia
    • UKM Medical Molecular Biology Institute (UMBI)University Kebangsaan Malaysia
Article

DOI: 10.1007/s10528-011-9472-2

Cite this article as:
Saif-Ali, R., Harun, R., Kamaruddin, N.A. et al. Biochem Genet (2012) 50: 298. doi:10.1007/s10528-011-9472-2

Abstract

This study investigated the association of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) with type 2 diabetes with or without metabolic syndrome in Malaysia. Nine HNF4 alpha SNPs were genotyped in 390 type 2 diabetic subjects with metabolic syndrome, 135 type 2 diabetic subjects without metabolic syndrome, and 160 control subjects. The SNPs rs4810424, rs1884613, and rs2144908 were associated with protection against type 2 diabetes without metabolic syndrome (recessive P = 0.018, OR 0.32; P = 0.004, OR 0.25; P = 0.005, OR 0.24, respectively). The 6-SNP haplotype2 CCCGTC containing the risk genotype of these SNPs was associated with higher risk for type 2 diabetes with or without metabolic syndrome (P = 0.002, OR 2.2; P = 0.004, OR 3.1). These data suggest that HNF4 alpha SNPs and haplotypes contributed to increased type 2 diabetes risk in the Malaysian population.

Keywords

Hepatocyte nuclear factor 4 alpha Type 2 diabetes Metabolic syndrome Single nucleotide polymorphisms Haplotype

Copyright information

© Springer Science+Business Media, LLC 2011