Biochemical Genetics

, Volume 48, Issue 5, pp 538–547

Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase

  • Tanushree Bose
  • V. Saroja Voruganti
  • M. Elizabeth Tejero
  • J. Michael Proffit
  • Laura A. Cox
  • John L. VandeBerg
  • Michael C. Mahaney
  • Jeffrey Rogers
  • Jeanne H. Freeland-Graves
  • Shelley A. Cole
  • Anthony G. Comuzzie
Article

DOI: 10.1007/s10528-010-9337-0

Cite this article as:
Bose, T., Saroja Voruganti, V., Elizabeth Tejero, M. et al. Biochem Genet (2010) 48: 538. doi:10.1007/s10528-010-9337-0

Abstract

Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST.

Keywords

Nonalcoholic fatty liver disease Obesity Adipocyte size Genome scan QTL Aspartate aminotransferase 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Tanushree Bose
    • 1
    • 4
  • V. Saroja Voruganti
    • 2
  • M. Elizabeth Tejero
    • 2
  • J. Michael Proffit
    • 2
  • Laura A. Cox
    • 2
    • 3
  • John L. VandeBerg
    • 2
    • 3
  • Michael C. Mahaney
    • 2
    • 3
  • Jeffrey Rogers
    • 2
    • 3
  • Jeanne H. Freeland-Graves
    • 1
  • Shelley A. Cole
    • 2
  • Anthony G. Comuzzie
    • 2
    • 3
  1. 1.Division of Nutritional Sciences, Department of Human EcologyUniversity of Texas at AustinAustinUSA
  2. 2.Department of GeneticsSouthwest Foundation for Biomedical ResearchSan AntonioUSA
  3. 3.Southwest National Primate Research CenterSan AntonioUSA
  4. 4.Department of Food Science and NutritionCalifornia Polytechnic State UniversitySan Luis ObispoUSA

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