Article

BioControl

, Volume 57, Issue 3, pp 463-469

First online:

Metabolites from Pseudomonas brassicacearum with activity against the pink snow mould causing pathogen Microdochium nivale

  • Pierre F. AnderssonAffiliated withDepartment of Chemistry, Uppsala BioCenter, Swedish University of Agricultural Sciences
  • , Jolanta LevenforsAffiliated withMASE Laboratories AB
  • , Anders BrobergAffiliated withDepartment of Chemistry, Uppsala BioCenter, Swedish University of Agricultural Sciences Email author 

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Abstract

Bioassay-guided fractionation of cell-free culture supernatants of the bacterium Pseudomonas brassicacearum MA250 yielded three bioactive compounds (1–3). Compound 1 was identified as the unsaturated fatty acid γ-lactone piliferolide A, compound 2 as the not previously described open acid form of 1, and 3 as the compound SB-253514, which is an imide of a 3-O-rhamnosyl fatty acid and a bicyclic carbamate. All three compounds displayed moderate activity towards the pink snow mould causing pathogen Microdochium nivale, and may thus contribute to the previously observed biological control of this strain on M. nivale on wheat. Compound 1 further exhibited activity towards the human pathogen Aspergillus fumigatus, while compound 3 showed antifungal as well as antibacterial activity.

Keywords

Antibiosis Antifungal Biocontrol Microbial antagonism Microdochium nivale