, Volume 13, Issue 3, pp 215–235

Hormesis: why it is important to biogerontologists

  • Edward J. Calabrese
  • Ivo Iavicoli
  • Vittorio Calabrese
Review Article

DOI: 10.1007/s10522-012-9374-7

Cite this article as:
Calabrese, E.J., Iavicoli, I. & Calabrese, V. Biogerontology (2012) 13: 215. doi:10.1007/s10522-012-9374-7


This paper offers a broad assessment of the hormetic dose response and its relevance to biogerontology. The paper provides detailed background information on the historical foundations of hormesis, its quantitative features, mechanistic foundations, as well as how the hormesis concept could be further applied in the development of new therapeutic advances in the treatment of age-related diseases. The concept of hormesis has direct application to biogerontology not only affecting the quality of the aging process but also experimental attempts to extend longevity.


HormesisHormetinBiphasicU-shapedJ-shapedAdaptive response

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Edward J. Calabrese
    • 1
  • Ivo Iavicoli
    • 2
  • Vittorio Calabrese
    • 3
  1. 1.Department of Public Health, Environmental Health SciencesUniversity of MassachusettsAmherstUSA
  2. 2.Istituto di Medicina del LavoroUniversitá Cattolica del Sacro CuoreRomaItaly
  3. 3.Department of ChemistryUniversity of CataniaCataniaItaly