Biogerontology

, Volume 12, Issue 4, pp 329–347

Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans

Authors

    • Humboldt-Universität zu BerlinDepartment of Biology, Laboratory of Freshwater & Stress Ecology
  • Nadine Saul
    • Humboldt-Universität zu BerlinDepartment of Biology, Laboratory of Freshwater & Stress Ecology
  • Shumon Chakrabarti
    • Humboldt-Universität zu BerlinDepartment of Biology, Laboratory of Freshwater & Stress Ecology
  • Stephen R. Stürzenbaum
    • School of Biomedical & Health Sciences, Analytical and Environmental Science DivisionKing′s College London
  • Ralph Menzel
    • Humboldt-Universität zu BerlinDepartment of Biology, Laboratory of Freshwater & Stress Ecology
  • Christian E. W. Steinberg
    • Humboldt-Universität zu BerlinDepartment of Biology, Laboratory of Freshwater & Stress Ecology
Research Article

DOI: 10.1007/s10522-011-9334-7

Cite this article as:
Pietsch, K., Saul, N., Chakrabarti, S. et al. Biogerontology (2011) 12: 329. doi:10.1007/s10522-011-9334-7

Abstract

Quercetin, Caffeic- and Rosmarinic acid exposure extend lifespan in Caenorhabditis elegans. This comparative study uncovers basic common and contrasting underlying mechanisms: For all three compounds, life extension was characterized by hormetic dose response curves, but hsp-level expression was variable. Quercetin and Rosmarinic acid both suppressed bacterial growth; however, antibacterial properties were not the dominant reason for life extension. Exposure to Quercetin, Caffeic- and Rosmarinic acid resulted in reduced body size, altered lipid-metabolism and a tendency towards a delay in reproductive timing; however the total number of offspring was not affected. An indirect dietary restriction effect, provoked by either chemo-repulsion or diminished pharyngeal pumping was rejected. Quercetin and Caffeic acid were shown to increase the antioxidative capacity in vivo and, by means of a lipofuscin assay, reduce the oxidative damage in the nematodes. Finally, it was possible to demonstrate that the life and thermotolerance enhancing properties of Caffeic- and Rosmarinic acid both rely on osr-1, sek-1, sir-2.1 and unc-43 plus daf-16 in the case of Caffeic acid. Taken together, hormesis, in vivo antioxidative/prooxidative properties, modulation of genetic players, as well as the re-allocation of energy all contribute (to some extent and dependent on the polyphenol) to life extension.

Keywords

HormetinAntioxidantQuercetinCaffeic acidRosmarinic acidLongevityCaenorhabditis elegans

Supplementary material

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Supplementary material 1 (PDF 36 kb)
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Supplementary material 7 (PDF 37 kb)

Copyright information

© Springer Science+Business Media B.V. 2011